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PMID: 1978938 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Allelic loss of chromosomes 16q and 10q in human prostate cancer.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 87 ·No. 22 ·1990-11-00 ·Pages 8751-5

Carter BS, Ewing CM, Ward WS, Treiger BF, Aalders TW, Schalken JA, Epstein JI, Isaacs WB

Abstract

Recent advances in understanding the molecular genetics of common adult tumors have indicated that multiple genetic alterations including the activation of oncogenes and the inactivation of tumor suppressor genes are important in the pathogenesis of these tumors. Loss of heterozygosity is a hallmark of tumor suppressor gene inactivation and has been used to identify chromosomal regions that contain these genes. We have examined allelic loss in the most common tumor in men, prostate cancer. Twenty-eight prostate cancer specimens have been examined for loss of heterozygosity at 11 different chromosomal arms including 3p, 7q, 9q, 10p, 10q, 11p, 13q, 16p, 16q, 17p, and 18q. Fifty-four percent (13/24) of clinically localized tumors and 4 of 4 metastatic tumors showed loss of heterozygosity on at least one chromosome. Chromosomes 16q and 10q exhibited the highest frequency of loss of heterozygosity with 30% of tumors showing loss at these chromosomes. These data demonstrate that allelic loss is a common event in prostate cancer and suggest that chromosomes 16q and 10q may contain the sites of tumor suppressor genes important in the pathogenesis of human prostate cancer.

MeSH Terms
Alleles Blotting, Southern Chromosome Deletion Chromosome Mapping Chromosomes, Human, Pair 10 Chromosomes, Human, Pair 16 DNA Probes Genes, Tumor Suppressor Humans Male Polymorphism, Restriction Fragment Length Prostatic Neoplasms/genetics
Chemicals
DNA Probes
Authors & Affiliations
8 authors, click to expand affiliations / ORCID
Carter B S
Brady Urological Institute Research Laboratory, Johns Hopkins Medical Institutions, Baltimore, MD 21205.
Ewing C M
Ward W S
Treiger B F
Aalders T W
Schalken J A
Epstein J I
Isaacs W B
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.87.22.8751
Published
1990-11-00
Pages
8751-5
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC55037
Subset
IM
Grants
NCI NIH HHS · CA09314 · United States
External Links
PubMed source DOI: 10.1073/pnas.87.22.8751 PMC Full Text View journal details
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