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PMID: 19851336 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, N.I.H., Intramural Review

Non-muscle myosin II takes centre stage in cell adhesion and migration.

Nature reviews. Molecular cell biology ·Vol. 10 ·No. 11 ·2009-11-00 ·Pages 778-90

Vicente-Manzanares M, Ma X, Adelstein RS, Horwitz AR

Abstract

Non-muscle myosin II (NM II) is an actin-binding protein that has actin cross-linking and contractile properties and is regulated by the phosphorylation of its light and heavy chains. The three mammalian NM II isoforms have both overlapping and unique properties. Owing to its position downstream of convergent signalling pathways, NM II is central in the control of cell adhesion, cell migration and tissue architecture. Recent insight into the role of NM II in these processes has been gained from loss-of-function and mutant approaches, methods that quantitatively measure actin and adhesion dynamics and the discovery of NM II mutations that cause monogenic diseases.

MeSH Terms
Animals Cell Adhesion/physiology Cell Movement/physiology Humans Myosin Type II/metabolism
Chemicals
Myosin Type II
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Vicente-Manzanares Miguel
Department of Cell Biology, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA. [email protected]
Ma Xuefei
Adelstein Robert S
Horwitz Alan Rick
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Article Info
Journal
Nature reviews. Molecular cell biology
Abbr.
Nat Rev Mol Cell Biol
ISSN
1471-0080
DOI
10.1038/nrm2786
Email
[email protected]
Published
2009-11-00
Pages
778-90
Language
English
Region
England
NLM ID
100962782
PMCID
PMC2834236
Subset
IM
Grants
NIGMS NIH HHS · R01 GM023244-34 · United States
NIGMS NIH HHS · U54 GM064346 · United States
NIGMS NIH HHS · GM23244 · United States
NIGMS NIH HHS · U54 GM064346-09 · United States
Intramural NIH HHS · United States
NIGMS NIH HHS · R37 GM023244 · United States
NIGMS NIH HHS · U54-GM064346 · United States
NIGMS NIH HHS · R01 GM023244 · United States
External Links
PubMed source DOI: 10.1038/nrm2786 PMC Full Text View journal details
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