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PMID: 19965608 Published · ppublish English Journal Article Review

Proteomic insights into an expanded cellular role for cytoplasmic lipid droplets.

Journal of lipid research ·Vol. 51 ·No. 2 ·2010-02-00 ·Pages 262-73

Hodges BD, Wu CC

Abstract

Cytoplasmic lipid droplets (CLDs) are cellular structures composed of a neutral lipid core surrounded by a phospholipid monolayer of amphipathic lipids and a variety of proteins. CLDs have classically been regarded as cellular energy storage structures. However, recent proteomic studies reveal that, although many of the proteins found to associate with CLDs are connected to lipid metabolism, storage, and homeostasis, there are also proteins with no obvious connection to the classical function and typically associated with other cellular compartments. Such proteins are termed refugee proteins, and their presence suggests that CLDs may serve an expanded role as a dynamic protein storage site, providing a novel mechanism for the regulation of protein function and transport.

MeSH Terms
Animals Cytoplasm/chemistry,metabolism Humans Lipid Metabolism Lipids/chemistry Proteomics
Chemicals
Lipids
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Hodges Brittany D M
Department of Pharmacology, University of Colorado School of Medicine, Aurora, CO, USA.
Wu Christine C
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Article Info
Journal
Journal of lipid research
Abbr.
J Lipid Res
ISSN
1539-7262
DOI
10.1194/jlr.R003582
Published
2010-02-00
Epub
2009-00-03
Pages
262-73
Language
English
Region
United States
NLM ID
0376606
PMCID
PMC2803228
Subset
IM
External Links
PubMed source DOI: 10.1194/jlr.R003582 PMC Full Text View journal details
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