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PMID: 20101384 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

The environment within: how gut microbiota may influence metabolism and body composition.

Diabetologia ·Vol. 53 ·No. 4 ·2010-04-00 ·Pages 606-13

Vrieze A, Holleman F, Zoetendal EG, de Vos WM, Hoekstra JB, Nieuwdorp M

Abstract

Obesity, diabetes and consequently atherosclerotic vascular disease have become major health and public health issues worldwide. The increasing and staggering prevalence of obesity might not only be explained by nutritional habits or the reduction of energy expenditure through decreased physical activity. In addition, recent studies have focused on intestinal microbiota as environmental factors that increase energy yield from diet, regulate peripheral metabolism and thereby increase body weight. Obesity is associated with substantial changes in composition and metabolic function of gut microbiota, but the pathophysiological processes driving this bidirectional relationship have not been fully elucidated. This review discusses the relationships between the following: composition of gut microbiota, energy extracted from diet, synthesis of gut hormones involved in energy homeostasis, production of butyrate and the regulation of fat storage.

MeSH Terms
Atherosclerosis/epidemiology Bacteria/classification,isolation & purification,metabolism Body Composition Diabetes Mellitus/epidemiology Diabetic Angiopathies/epidemiology Diet Digestion Energy Metabolism/physiology Humans Intestines/microbiology Obesity/epidemiology,microbiology Phylogeny Prevalence
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Vrieze A
Department of Internal and Vascular Medicine, Academic Medical Centre, Meibergdreef 9, room F4-159.2, 1105, AZ Amsterdam, the Netherlands.
Holleman F
Zoetendal E G
de Vos W M
Hoekstra J B L
Nieuwdorp M
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Article Info
Journal
Diabetologia
Abbr.
Diabetologia
ISSN
1432-0428
DOI
10.1007/s00125-010-1662-7
Published
2010-04-00
Epub
2010-00-26
Pages
606-13
Language
English
Region
Germany
NLM ID
0006777
PMCID
PMC2830587
Subset
IM
External Links
PubMed source DOI: 10.1007/s00125-010-1662-7 PMC Full Text View journal details
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