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PMID: 2017177 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Murine and human T-lymphocyte GATA-3 factors mediate transcription through a cis-regulatory element within the human T-cell receptor delta gene enhancer.

Molecular and cellular biology ·Vol. 11 ·No. 5 ·1991-05-00 ·Pages 2778-84

Ko LJ, Yamamoto M, Leonard MW, George KM, Ting P, Engel JD

Abstract

A family of transcriptional activators has recently been identified in chickens; these transcriptional activators recognize a common consensus motif (WGATAR) through a conserved C4 zinc finger DNA-binding domain. One of the members of this multigene family, cGATA-3, is most abundantly expressed in the T-lymphocyte cell lineage. Analysis of human and murine GATA-3 factors shows a striking degree of amino acid sequence identity and similar patterns of tissue specificity of expression in these three organisms. The murine and human factors are abundantly expressed in a variety of human and murine T-cell lines and can activate transcription through a tissue-specific GATA-binding site identified within the human T-cell receptor delta gene enhancer. We infer that the murine and human GATA-3 proteins play a central and highly conserved role in vertebrate T-cell-specific transcriptional regulation.

MeSH Terms
Amino Acid Sequence Animals Base Sequence Cell Line Chickens DNA-Binding Proteins/genetics,metabolism Enhancer Elements, Genetic GATA3 Transcription Factor Gene Library Globins/genetics Humans Mice Molecular Sequence Data Multigene Family Oligonucleotide Probes Rabbits Receptors, Antigen, T-Cell/genetics Regulatory Sequences, Nucleic Acid Sequence Homology, Nucleic Acid T-Lymphocytes/immunology TATA Box Trans-Activators/genetics,metabolism Transcription Factors/genetics Transcription, Genetic Transfection
Chemicals
DNA-Binding Proteins GATA3 Transcription Factor GATA3 protein, human Gata3 protein, mouse Oligonucleotide Probes Receptors, Antigen, T-Cell Trans-Activators Transcription Factors Globins
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Ko L J
Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, Illinois 60208-3500.
Yamamoto M
Leonard M W
George K M
Ting P
Engel J D
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Article Info
Journal
Molecular and cellular biology
Abbr.
Mol Cell Biol
ISSN
0270-7306
DOI
10.1128/mcb.11.5.2778-2784.1991
Published
1991-05-00
Pages
2778-84
Language
English
Region
United States
NLM ID
8109087
PMCID
PMC360054
Subset
IM
Grants
NIGMS NIH HHS · GM 08061 · United States
NIGMS NIH HHS · GM 28896 · United States
NHLBI NIH HHS · HL 24415 · United States
Databases
GENBANK
M64822, M64823, M64824, M64825, M64826, M64827, X55122, X55123, X56930, X56931
External Links
PubMed source DOI: 10.1128/mcb.11.5.2778-2784.1991 PMC Full Text View journal details
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