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PMID: 2024969 Published · ppublish English Journal Article

Uptake of sparfloxacin and norfloxacin by clinical isolates of Staphylococcus aureus.

Antimicrobial agents and chemotherapy ·Vol. 35 ·No. 2 ·1991-02-00 ·Pages 368-70

Yoshida S, Kojima T, Inoue M, Mitsuhashi S

Abstract

The amount of sparfloxacin uptake was higher than that of norfloxacin uptake in Staphylococcus aureus. Moreover, energy-dependent reduction in quinolone uptake, probably due to active efflux of the quinolone, was observed. The reduction in quinolone uptake appeared to be associated with quinolone resistance in S. aureus.

MeSH Terms
Anti-Infective Agents/metabolism,pharmacology Carbonyl Cyanide m-Chlorophenyl Hydrazone/pharmacology Drug Resistance, Microbial Fluoroquinolones Microbial Sensitivity Tests Norfloxacin/metabolism Staphylococcal Infections/microbiology Staphylococcus aureus/drug effects,metabolism
Chemicals
Anti-Infective Agents Fluoroquinolones Carbonyl Cyanide m-Chlorophenyl Hydrazone Norfloxacin sparfloxacin
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Yoshida S
Episome Institute, Gunma, Japan.
Kojima T
Inoue M
Mitsuhashi S
References (15)
15 references, click to expand
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Article Info
Journal
Antimicrobial agents and chemotherapy
Abbr.
Antimicrob Agents Chemother
ISSN
0066-4804
DOI
10.1128/AAC.35.2.368
Published
1991-02-00
Pages
368-70
Language
English
Region
United States
NLM ID
0315061
PMCID
PMC245007
Subset
IM
External Links
PubMed source DOI: 10.1128/AAC.35.2.368 PMC Full Text View journal details
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