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PMID: 20453074 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Review

Chromatin-mediated epigenetic regulation in the malaria parasite Plasmodium falciparum.

Eukaryotic cell ·Vol. 9 ·No. 8 ·2010-08-00 ·Pages 1138-49

Cui L, Miao J

Abstract

Malaria is a major public health problem in many developing countries, with the malignant tertian parasite Plasmodium falciparum causing the most malaria-associated mortality. Extensive research, especially with the advancement of genomics and transfection tools, has highlighted the fundamental importance of chromatin-mediated gene regulation in the developmental program of this early-branching eukaryote. The Plasmodium parasite genomes reveal the existence of both canonical and variant histones that make up the nucleosomes, as well as a full collection of conserved enzymes for chromatin remodeling and histone posttranslational modifications (PTMs). Recent studies have identified a wide array of both conserved and novel histone PTMs in P. falciparum, indicating the presence of a complex and divergent "histone code." Genome-wide analysis has begun to decipher the nucleosome landscape and histone modifications associated with the dynamic organization of chromatin structures during the parasite's life cycle. Focused studies on malaria-specific phenomena such as antigenic variation and red cell invasion pathways shed further light on the involvement of epigenetic mechanisms in these processes. Here we review our current understanding of chromatin-mediated gene regulation in malaria parasites, with specific reference to exemplar studies on antigenic variation and host cell invasion.

MeSH Terms
Chromatin/metabolism Epigenesis, Genetic Histones/metabolism Malaria, Falciparum/parasitology Models, Genetic Plasmodium falciparum/genetics,growth & development
Chemicals
Chromatin Histones
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Cui Liwang
Department of Entomology, Pennsylvania State University, 501 ASI Bldg., University Park, PA 16802, USA. [email protected]
Miao Jun
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Article Info
Journal
Eukaryotic cell
Abbr.
Eukaryot Cell
ISSN
1535-9786
DOI
10.1128/EC.00036-10
Email
[email protected]
Published
2010-08-00
Epub
2010-00-07
Pages
1138-49
Language
English
Region
United States
NLM ID
101130731
PMCID
PMC2918932
Subset
IM
Grants
NIAID NIH HHS · R01 AI064553 · United States
External Links
PubMed source DOI: 10.1128/EC.00036-10 PMC Full Text
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