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PMID: 20520716 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Natural allelic variation underlying a major fitness trade-off in Arabidopsis thaliana.

Nature ·Vol. 465 ·No. 7298 ·2010-06-03 ·Pages 632-6

Todesco M, Balasubramanian S, Hu TT, Traw MB, Horton M, Epple P, Kuhns C, Sureshkumar S, Schwartz C, Lanz C, Laitinen RA, Huang Y, Chory J, Lipka V, Borevitz JO, Dangl JL, Bergelson J, Nordborg M, Weigel D

Abstract

Plants can defend themselves against a wide array of enemies, from microbes to large animals, yet there is great variability in the effectiveness of such defences, both within and between species. Some of this variation can be explained by conflicting pressures from pathogens with different modes of attack. A second explanation comes from an evolutionary 'tug of war', in which pathogens adapt to evade detection, until the plant has evolved new recognition capabilities for pathogen invasion. If selection is, however, sufficiently strong, susceptible hosts should remain rare. That this is not the case is best explained by costs incurred from constitutive defences in a pest-free environment. Using a combination of forward genetics and genome-wide association analyses, we demonstrate that allelic diversity at a single locus, ACCELERATED CELL DEATH 6 (ACD6), underpins marked pleiotropic differences in both vegetative growth and resistance to microbial infection and herbivory among natural Arabidopsis thaliana strains. A hyperactive ACD6 allele, compared to the reference allele, strongly enhances resistance to a broad range of pathogens from different phyla, but at the same time slows the production of new leaves and greatly reduces the biomass of mature leaves. This allele segregates at intermediate frequency both throughout the worldwide range of A. thaliana and within local populations, consistent with this allele providing substantial fitness benefits despite its marked impact on growth.

MeSH Terms
Alleles Ankyrins/genetics,metabolism Arabidopsis/genetics,growth & development,metabolism,microbiology Arabidopsis Proteins/genetics,metabolism Biomass Gene Expression Regulation, Plant Genes, Plant Genetic Fitness/genetics Genetic Variation/genetics Genome-Wide Association Study Molecular Sequence Data Phenotype Plant Diseases/genetics,microbiology Plant Leaves/anatomy & histology,genetics,growth & development,parasitology Quantitative Trait Loci
Chemicals
ACD6 protein, Arabidopsis Ankyrins Arabidopsis Proteins
Authors & Affiliations
19 authors, click to expand affiliations / ORCID
Todesco Marco
Department of Molecular Biology, Max Planck Institute for Developmental Biology, 72076 Tübingen, Germany.
Balasubramanian Sureshkumar
Hu Tina T
Traw M Brian
Horton Matthew
Epple Petra
Kuhns Christine
Sureshkumar Sridevi
Schwartz Christopher
Lanz Christa
Laitinen Roosa A E
Huang Yu
Chory Joanne
Lipka Volker
Borevitz Justin O
Dangl Jeffery L
Bergelson Joy
Nordborg Magnus
Weigel Detlef
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Article Info
Journal
Nature
Abbr.
Nature
ISSN
1476-4687
DOI
10.1038/nature09083
Published
2010-06-03
Pages
632-6
Language
English
Region
England
NLM ID
0410462
PMCID
PMC3055268
Subset
IM
Grants
NIGMS NIH HHS · R01 GM057171 · United States
NIGMS NIH HHS · GM073822 · United States
NIGMS NIH HHS · R01 GM062932 · United States
NIGMS NIH HHS · F23-GM65032-1 · United States
NIGMS NIH HHS · R01 GM057994 · United States
Howard Hughes Medical Institute · United States
NIGMS NIH HHS · R01 GM062932-08 · United States
NIGMS NIH HHS · R01 GM073822 · United States
NIGMS NIH HHS · GM62932 · United States
NIGMS NIH HHS · GM057171 · United States
NIGMS NIH HHS · GM057994 · United States
NIGMS NIH HHS · F32 GM065032 · United States
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PubMed source DOI: 10.1038/nature09083 PMC Full Text View journal details
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