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PMID: 20538376 Published · ppublish English Comparative Study Journal Article Multicenter Study Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

3D maps localize caudate nucleus atrophy in 400 Alzheimer's disease, mild cognitive impairment, and healthy elderly subjects.

Neurobiology of aging ·Vol. 31 ·No. 8 ·2010-08-00 ·Pages 1312-25

Madsen SK, Ho AJ, Hua X, Saharan PS, Toga AW, Jack CR, Weiner MW, Thompson PM, Alzheimer's Disease Neuroimaging Initiative

Abstract

MRI research examining structural brain atrophy in Alzheimer's disease (AD) generally focuses on medial temporal and cortical structures, but amyloid and tau deposits also accumulate in the caudate. Here we mapped the 3D profile of caudate atrophy using a surface mapping approach in subjects with AD and mild cognitive impairment (MCI) to identify potential clinical and pathological correlates. 3D surface models of the caudate were automatically extracted from 400 baseline MRI scans (100 AD, 200 MCI, 100 healthy elderly). Compared to controls, caudate volumes were lower in MCI (2.64% left, 4.43% right) and AD (4.74% left, 8.47% right). Caudate atrophy was associated with age, sum-of-boxes and global Clinical Dementia Ratings, Delayed Logical Memory scores, MMSE decline 1 year later, and body mass index. Reduced right (but not left) volume was associated with MCI-to-AD conversion and CSF tau levels. Normal caudate asymmetry (with the right 3.9% larger than left) was lost in AD, suggesting preferential right caudate atrophy. Automated caudate maps may complement other MRI-derived measures of disease burden in AD.

MeSH Terms
Aged Aged, 80 and over Alzheimer Disease/pathology,psychology Atrophy Brain Mapping/methods Caudate Nucleus/pathology Cognition Disorders/pathology,psychology Female Humans Imaging, Three-Dimensional Longitudinal Studies Male Prospective Studies
Authors & Affiliations
9 authors, click to expand affiliations / ORCID
Madsen S K
Laboratory of Neuro Imaging, Department of Neurology, University of California, Los Angeles, School of Medicine, Los Angeles, CA, USA.
Ho A J
Hua X
Saharan P S
Toga A W
Jack C R
Weiner M W
Thompson P M
Alzheimer's Disease Neuroimaging Initiative
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Article Info
Journal
Neurobiology of aging
Abbr.
Neurobiol Aging
ISSN
1558-1497
DOI
10.1016/j.neurobiolaging.2010.05.002
Published
2010-08-00
Epub
2010-00-11
Pages
1312-25
Language
English
Region
United States
NLM ID
8100437
PMCID
PMC2903198
Subset
IM
Grants
NIA NIH HHS · K01 AG030514 · United States
NIA NIH HHS · U01 AG024904-04 · United States
NIA NIH HHS · P30 AG010129-19 · United States
NIA NIH HHS · U01 AG024904-06 · United States
NIA NIH HHS · P30 AG010129 · United States
NIA NIH HHS · K01 AG030514-02 · United States
NIA NIH HHS · K01 AG030514-04 · United States
NIA NIH HHS · U01 AG024904 · United States
NIA NIH HHS · U19 AG010483 · United States
External Links
PubMed source DOI: 10.1016/j.neurobiolaging.2010.05.002 PMC Full Text View journal details
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