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PMID: 20634425 Published · ppublish English Journal Article Research Support, N.I.H., Extramural

Unique precursors for the mesenchymal cells involved in injury response and fibrosis.

Walker JL, Zhai N, Zhang L, Bleaken BM, Wolff I, Gerhart J, George-Weinstein M, Menko AS

Abstract

We investigated an alternative pathway for emergence of the mesenchymal cells involved in epithelial sheet wound healing and a source of myofibroblasts that cause fibrosis. Using a mock cataract surgery model, we discovered a unique subpopulation of polyploid mesenchymal progenitors nestled in small niches among lens epithelial cells that expressed the surface antigen G8 and mRNA for the myogenic transcription factor MyoD. These cells rapidly responded to wounding of the lens epithelium with population expansion, acquisition of a mesenchymal phenotype, and migration to the wound edges where they regulate the wound response of the epithelium. These mesenchymal cells also were a principal source of myofibroblasts that emerged following lens injury and were responsible for fibrotic disease of the lens that occurs following cataract surgery. These studies provide insight into the mechanisms of wound-healing and fibrosis.

MeSH Terms
Animals Antigens, Surface/metabolism Cell Differentiation Chick Embryo Fibrosis/genetics,metabolism Gene Expression Regulation Mesenchymal Stem Cells/cytology,metabolism MyoD Protein/genetics Wound Healing
Chemicals
Antigens, Surface MyoD Protein
Authors & Affiliations
8 authors, click to expand affiliations / ORCID
Walker Janice L
Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Zhai Ni
Zhang Liping
Bleaken Brigid M
Wolff Iris
Gerhart Jacquelyn
George-Weinstein Mindy
Menko A Sue
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
1091-6490
Published
2010-08-03
Epub
2010-00-15
Pages
13730-5
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC2922264
Subset
IM
Grants
NEI NIH HHS · EY014798 · United States
NEI NIH HHS · R01 EY014258 · United States
NIAMS NIH HHS · AR052326 · United States
NIAMS NIH HHS · R01 AR052326 · United States
NEI NIH HHS · EY010577 · United States
NEI NIH HHS · R01 EY010577 · United States
NEI NIH HHS · R21 EY019571 · United States
NEI NIH HHS · EY019571 · United States
NEI NIH HHS · EY014258 · United States
NEI NIH HHS · R24 EY014798 · United States
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