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PMID: 206902 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Pseudotypes of feline sarcoma virus contain an 85,000-dalton protein with feline oncornavirus-associated cell membrane antigen (FOCMA) activity.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 75 ·No. 3 ·1978-03-00 ·Pages 1505-9

Sherr CJ, Sen A, Todaro GJ, Sliski A, Essex M

Abstract

Feline sarcoma virus (FeSV) rescued from transformed nonproducer mink or rat cells contains two FeSV-specific antigens (p15 and p12), and the feline oncornavirus-associated cell membrane antigen (FOCMA). All three antigens are helper virus-independent and are encoded by the FeSV genome, FOCMA, p15, and p12 antigens cochromatograph as phosphorylated molecules of 85,000 molecular weight (pp85), adsorb to immunoadsorbant columns prepared with antibodies to feline leukemia virus (FeLV), and are precipitated with antisera to FeLV or FOCMA. Antibodies to FOCMA can be adsorbed with fractions containing pp85 but not with FeLV proteins, including p15 and p12. Thus, a virus-coded tumor antigen which immunizes cats against tumors induced by feline type C viruses is packaged in FeSV particles and is linked to viral structural protein.

MeSH Terms
Antigens, Neoplasm/genetics Antigens, Viral/genetics Cell Line Cell Membrane/immunology Cell Transformation, Viral Defective Viruses/genetics,immunology Genes, Viral Molecular Weight Retroviridae/immunology Sarcoma Viruses, Feline/genetics,immunology Viral Proteins/immunology
Chemicals
Antigens, Neoplasm Antigens, Viral Viral Proteins
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Sherr C J
Sen A
Todaro G J
Sliski A
Essex M
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34 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.75.3.1505
Published
1978-03-00
Pages
1505-9
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC411501
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.75.3.1505 PMC Full Text View journal details
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