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PMID: 49443 Published · ppublish English Comparative Study Journal Article Research Support, U.S. Gov't, P.H.S.

Interspecies antigenic determinants of the reverse transcriptases and p30 proteins of mammalian type C viruses.

Journal of virology ·Vol. 15 ·No. 6 ·1975-06-00 ·Pages 1440-8

Sherr CJ, Fedele LA, Benveniste RE, Todaro GJ

Abstract

The major internal structural proteins (p30) of type C viruses isolated from several mammalian species were studied by radioimmunoprecipitation and competitive radioimmunoassays. Three antigenically distinguishable sets of interspecies determinants could be demonstrated by both methods. One set of determinants shared by viruses of rodent origin (mouse and rat) can be detected readily in feline leukemia viruses but not in other type C viral groups. The p30 proteins of murine viruses also contain a second discrete set of antigenic determinants related to those in infectious primate viruses and endogenous porcine viruses, but not detected in the feline leukemia virus group. The p30 proteins of endogenous viruses of baboons and domestic cats share yet a third set of cross-reactive determinants not detected in type C viruses isolated from other species of animals. Enzyme inhibition studies performed with antisera raised toward the reverse transcriptases of these same groups of type C viruses showed the same patterns of immunological cross-reactions as observed with p30 proteins. The antigenic cross-reactions between the homologous proteins of type C virus isolated from genetically distant animals may reflect transmission of type C viruses across species barriers.

MeSH Terms
Animals Cats Chloramines Cross Reactions Epitopes Gammaretrovirus/immunology Haplorhini Hylobates Immunoglobulin G Iodine Radioisotopes Leukemia Virus, Feline/immunology Papio RNA-Directed DNA Polymerase/immunology,metabolism Radioimmunoassay Rats Rauscher Virus/immunology Retroviridae/immunology Swine Viral Proteins/immunology
Chemicals
Chloramines Epitopes Immunoglobulin G Iodine Radioisotopes Viral Proteins RNA-Directed DNA Polymerase
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Sherr C J
Fedele L A
Benveniste R E
Todaro G J
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.15.6.1440-1448.1975
Published
1975-06-00
Pages
1440-8
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC354611
Subset
IM
External Links
PubMed source DOI: 10.1128/JVI.15.6.1440-1448.1975 PMC Full Text View journal details
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