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PMID: 20976252 Published · epublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Host genetics and HIV-1: the final phase?

PLoS pathogens ·Vol. 6 ·No. 10 ·2010-10-14 ·Pages e1001033

Fellay J, Shianna KV, Telenti A, Goldstein DB

Abstract

This is a crucial transition time for human genetics in general, and for HIV host genetics in particular. After years of equivocal results from candidate gene analyses, several genome-wide association studies have been published that looked at plasma viral load or disease progression. Results from other studies that used various large-scale approaches (siRNA screens, transcriptome or proteome analysis, comparative genomics) have also shed new light on retroviral pathogenesis. However, most of the inter-individual variability in response to HIV-1 infection remains to be explained: genome resequencing and systems biology approaches are now required to progress toward a better understanding of the complex interactions between HIV-1 and its human host.

MeSH Terms
Cohort Studies Disease Progression Genetic Variation/physiology HIV Infections/genetics,pathology,prevention & control,therapy HIV-1/genetics,pathogenicity Host-Pathogen Interactions/genetics Humans Infection Control Models, Biological Treatment Outcome
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Fellay Jacques
Center for Human Genome Variation, Duke University School of Medicine, Durham, North Carolina, United States of America. [email protected]
Shianna Kevin V
Telenti Amalio
Goldstein David B
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Article Info
Journal
PLoS pathogens
Abbr.
PLoS Pathog
ISSN
1553-7374
DOI
10.1371/journal.ppat.1001033
Email
[email protected]
Published
2010-10-14
Epub
2010-00-14
Pages
e1001033
Language
English
Region
United States
NLM ID
101238921
PMCID
PMC2954832
Subset
IM
Grants
NIAID NIH HHS · U01 AI067854 · United States
NIAID NIH HHS · U19 AI067854 · United States
NIAID NIH HHS · AI067854 · United States
External Links
PubMed source DOI: 10.1371/journal.ppat.1001033 PMC Full Text View journal details
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