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PMID: 18976921 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, N.I.H., Intramural Research Support, Non-U.S. Gov't Review

KIR-HLA intercourse in HIV disease.

Trends in microbiology ·Vol. 16 ·No. 12 ·2008-12-00 ·Pages 620-7

Carrington M, Martin MP, van Bergen J

Abstract

Human leukocyte antigen (HLA) class I loci are essential to an effective immune response against a wide variety of pathogenic microorganisms, and they represent the prototypes for genetic polymorphism that are sustained through balancing selection. The functional significance of HLA class I variation is better exemplified by studies involving HIV type 1 (HIV-1) than any other infectious organism. HLA class I molecules are essential to the acquired immune response, but they are also important in innate immunity as ligands for the killer cell immunoglobulin-like receptors (KIR), which modulate natural killer cell activity. Here we concentrate on the interaction between the HLA-B and KIR3DL1/KIR3DS1 genes, describe the effects of these loci on HIV disease, and discuss questions that remain unresolved.

MeSH Terms
Disease Progression HIV Infections/immunology,physiopathology,virology HIV-1/pathogenicity HLA Antigens/metabolism HLA-B Antigens/metabolism Humans Killer Cells, Natural/immunology Receptors, KIR/metabolism Receptors, KIR3DL1/metabolism Receptors, KIR3DS1/metabolism
Chemicals
HLA Antigens HLA-B Antigens Receptors, KIR Receptors, KIR3DL1 Receptors, KIR3DS1
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Carrington Mary
Cancer and Inflammation Program, Laboratory of Experimental Immunology, SAIC-Frederick, Inc., NCI-Frederick, Frederick, MD 21702, USA. [email protected]
Martin Maureen P
van Bergen Jeroen
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Article Info
Journal
Trends in microbiology
Abbr.
Trends Microbiol
ISSN
0966-842X
DOI
10.1016/j.tim.2008.09.002
Email
[email protected]
Published
2008-12-00
Epub
2008-00-29
Pages
620-7
Language
English
Region
England
NLM ID
9310916
PMCID
PMC3463869
Subset
IM
Grants
NCI NIH HHS · N01CO12400 · United States
Intramural NIH HHS · ZIA BC010791-04 · United States
NCI NIH HHS · N01-CO-12400 · United States
External Links
PubMed source DOI: 10.1016/j.tim.2008.09.002 PMC Full Text View journal details
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