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PMID: 21029958 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Designing vaccines based on biology of human dendritic cell subsets.

Immunity ·Vol. 33 ·No. 4 ·2010-10-29 ·Pages 464-78

Palucka K, Banchereau J, Mellman I

Abstract

The effective vaccines developed against a variety of infectious agents, including polio, measles, and hepatitis B, represent major achievements in medicine. These vaccines, usually composed of microbial antigens, are often associated with an adjuvant that activates dendritic cells (DCs). Many infectious diseases are still in need of an effective vaccine including HIV, malaria, hepatitis C, and tuberculosis. In some cases, the induction of cellular rather than humoral responses may be more important because the goal is to control and eliminate the existing infection rather than to prevent it. Our increased understanding of the mechanisms of antigen presentation, particularly with the description of DC subsets with distinct functions, as well as their plasticity in responding to extrinsic signals, represent opportunities to develop novel vaccines. In addition, we foresee that this increased knowledge will permit us to design vaccines that will reprogram the immune system to intervene therapeutically in cancer, allergy, and autoimmunity.

MeSH Terms
Antigens/immunology CD4-Positive T-Lymphocytes/immunology CD8-Positive T-Lymphocytes/immunology Cancer Vaccines/therapeutic use Dendritic Cells/immunology Drug Design Humans Skin/immunology Stem Cells/immunology Vaccines/immunology
Chemicals
Antigens Cancer Vaccines Vaccines
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Palucka Karolina
Baylor Institute for Immunology Research, 3434 Live Oak Avenue, Dallas, TX 75204, USA. [email protected]
Banchereau Jacques
Mellman Ira
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Article Info
Journal
Immunity
Abbr.
Immunity
ISSN
1097-4180
DOI
10.1016/j.immuni.2010.10.007
Email
[email protected]
Published
2010-10-29
Pages
464-78
Language
English
Region
United States
NLM ID
9432918
PMCID
PMC2975953
Subset
IM
Grants
NCI NIH HHS · R01 CA140602 · United States
NCI NIH HHS · P01 CA084512 · United States
NCI NIH HHS · CA078846 · United States
PHS HHS · U19 AIO57234 · United States
NIAID NIH HHS · U19 AI057234 · United States
NCI NIH HHS · R01 CA089440 · United States
NCI NIH HHS · R01 CA078846 · United States
NCI NIH HHS · P01 CA084514 · United States
External Links
PubMed source DOI: 10.1016/j.immuni.2010.10.007 PMC Full Text View journal details
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