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PMID: 21248839 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Autophagy in immunity and inflammation.

Nature ·Vol. 469 ·No. 7330 ·2011-01-20 ·Pages 323-35

Levine B, Mizushima N, Virgin HW

Abstract

Autophagy is an essential, homeostatic process by which cells break down their own components. Perhaps the most primordial function of this lysosomal degradation pathway is adaptation to nutrient deprivation. However, in complex multicellular organisms, the core molecular machinery of autophagy - the 'autophagy proteins' - orchestrates diverse aspects of cellular and organismal responses to other dangerous stimuli such as infection. Recent developments reveal a crucial role for the autophagy pathway and proteins in immunity and inflammation. They balance the beneficial and detrimental effects of immunity and inflammation, and thereby may protect against infectious, autoimmune and inflammatory diseases.

MeSH Terms
Animals Autophagy/immunology,physiology Cell Membrane/metabolism Humans Immunity/immunology,physiology Immunity, Innate/immunology,physiology Infections/immunology,microbiology,parasitology,virology Inflammation/immunology,microbiology,pathology Phagosomes/immunology,microbiology,parasitology,virology
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Levine Beth
Department of Microbiology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390-9113, USA. [email protected]
Mizushima Noboru
Virgin Herbert W
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Article Info
Journal
Nature
Abbr.
Nature
ISSN
1476-4687
DOI
10.1038/nature09782
Email
[email protected]
Published
2011-01-20
Pages
323-35
Language
English
Region
England
NLM ID
0410462
PMCID
PMC3131688
Subset
IM
Grants
NIAID NIH HHS · R01 AI084887 · United States
NIAID NIH HHS · U54 AI057156 · United States
NCI NIH HHS · R01 CA109618-07 · United States
Howard Hughes Medical Institute · United States
NIAID NIH HHS · R01 AI054483 · United States
NIAID NIH HHS · U54 AI057160 · United States
NCI NIH HHS · R01 CA109618 · United States
NCI NIH HHS · R01 CA096511 · United States
External Links
PubMed source DOI: 10.1038/nature09782 PMC Full Text View journal details
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