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PMID: 21248841 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

The Polycomb complex PRC2 and its mark in life.

Nature ·Vol. 469 ·No. 7330 ·2011-01-20 ·Pages 343-9

Margueron R, Reinberg D

Abstract

Polycomb group proteins maintain the gene-expression pattern of different cells that is set during early development by regulating chromatin structure. In mammals, two main Polycomb group complexes exist - Polycomb repressive complex 1 (PRC1) and 2 (PRC2). PRC1 compacts chromatin and catalyses the monoubiquitylation of histone H2A. PRC2 also contributes to chromatin compaction, and catalyses the methylation of histone H3 at lysine 27. PRC2 is involved in various biological processes, including differentiation, maintaining cell identity and proliferation, and stem-cell plasticity. Recent studies of PRC2 have expanded our perspectives on its function and regulation, and uncovered a role for non-coding RNA in the recruitment of PRC2 to target genes.

MeSH Terms
Animals Cell Differentiation/genetics Chromatin/genetics,metabolism Evolution, Molecular Genome/genetics Histone-Lysine N-Methyltransferase/chemistry,metabolism Histones/chemistry,metabolism Humans Methylation Neoplasms/genetics,metabolism Polycomb-Group Proteins Repressor Proteins/chemistry,metabolism
Chemicals
Chromatin Histones Polycomb-Group Proteins Repressor Proteins Histone-Lysine N-Methyltransferase
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Margueron Raphaël
Institut Curie, 26 Rue d'Ulm, 75005 Paris, France.
Reinberg Danny
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Article Info
Journal
Nature
Abbr.
Nature
ISSN
1476-4687
DOI
10.1038/nature09784
Published
2011-01-20
Pages
343-9
Language
English
Region
England
NLM ID
0410462
PMCID
PMC3760771
Subset
IM
Grants
NIGMS NIH HHS · R01GM064844 · United States
NIGMS NIH HHS · 4R37GM037120 · United States
NIGMS NIH HHS · R37 GM037120 · United States
Howard Hughes Medical Institute · United States
NIGMS NIH HHS · R01 GM064844 · United States
External Links
PubMed source DOI: 10.1038/nature09784 PMC Full Text View journal details
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