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PMID: 2140073 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Chicken atrial natriuretic peptide (chANP) and its secretion.

Cell and tissue research ·Vol. 259 ·No. 2 ·1990-02-00 ·Pages 293-8

Toshimori H, Toshimori K, Minamino N, Kangawa K, Oura C, Matsukura S, Matsuo H

Abstract

An immunohistochemical study using antiserum raised against synthetic chicken natriuretic polypeptide was used to investigate the distribution of this peptide in the chicken heart. Immunoreactive cells, both in the atrial and ventricular walls, were identified by electron microscopy, and electron-dense granules in the atrial and ventricular cardiocytes were revealed to be storage sites of the peptide. The electron-dense material, thought to be the peptide, was found in the sarcoplasmic reticulum, and it is suggested that a secretory pathway of the peptide through the latter to extracellular space, may be present, in addition to an exocytotic one.

MeSH Terms
Aging/metabolism Animals Atrial Natriuretic Factor/metabolism Chick Embryo Chickens Cytoplasmic Granules/metabolism,ultrastructure Female Heart/embryology Myocardium/metabolism,ultrastructure
Chemicals
Atrial Natriuretic Factor
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Toshimori H
Third Division of Internal Medicine, Miyazaki Medical College, Japan.
Toshimori K
Minamino N
Kangawa K
Oura C
Matsukura S
Matsuo H
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19 references, click to expand
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Article Info
Journal
Cell and tissue research
Abbr.
Cell Tissue Res
ISSN
0302-766X
DOI
10.1007/BF00318451
Published
1990-02-00
Pages
293-8
Language
English
Region
Germany
NLM ID
0417625
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00318451 View journal details
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