The distribution of atrial natriuretic polypeptide (ANP)-containing cells in the adult rat heart.

Anatomy and embryology ·Vol. 177 ·No. 6 ·1988-00-00 ·Pages 477-84

Toshimori H, Toshimori K, Oura C, Matsuo H, Matsukura S

Abstract

The present study was performed to clarify the distribution of ANP-containing cells in the adult rat heart by immunostaining for ANP using antiserum against alpha-human ANP. ANP-immunoreactive cells were generally present in the atrial walls except for the sinoatrial node. In the ventricular walls, they were distributed in the impulse conducting system, particularly the left bundle branch, Purkinje fibers on the left side of the interventricular septum, and those in the false tendons in the left ventricle, while they were sporadically seen in the atrioventricular node and bundle of His. The immunoreactive cells contained specific granules that were positive for ANP. These findings demonstrate that ANP-containing cells are present in the atrial and ventricular walls.

MeSH Terms

Animals Atrial Natriuretic Factor/analysis,immunology Heart Atria/ultrastructure Immunohistochemistry Inclusion Bodies Male Microscopy, Electron Myocardium/analysis,cytology,immunology Rats Rats, Inbred Strains

Chemicals

Atrial Natriuretic Factor

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Toshimori H

Department of Internal Medicine, Miyazaki Medical College, Japan.

Toshimori K

Oura C

Matsuo H

Matsukura S

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Article Info

Journal

Anatomy and embryology

Abbr.

Anat Embryol (Berl)

ISSN

0340-2061

DOI

10.1007/BF00305135

Published

1988-00-00

Pages

477-84

Language

English

Region

Germany

NLM ID

7505194

Subset

External Links

PubMed source DOI: 10.1007/BF00305135

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The distribution of atrial natriuretic polypeptide (ANP)-containing cells in the adult rat heart.

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