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PMID: 21508983 Published · ppublish English Journal Article Research Support, N.I.H., Intramural Review

Harnessing the biology of IL-7 for therapeutic application.

Nature reviews. Immunology ·Vol. 11 ·No. 5 ·2011-05-00 ·Pages 330-42

Mackall CL, Fry TJ, Gress RE

Abstract

Interleukin-7 (IL-7) is required for T cell development and for maintaining and restoring homeostasis of mature T cells. IL-7 is a limiting resource under normal conditions, but it accumulates during lymphopaenia, leading to increased T cell proliferation. The administration of recombinant human IL-7 to normal or lymphopenic mice, non-human primates and humans results in widespread T cell proliferation, increased T cell numbers, modulation of peripheral T cell subsets and increased T cell receptor repertoire diversity. These effects raise the prospect that IL-7 could mediate therapeutic benefits in several clinical settings. This Review summarizes the biology of IL-7 and the results of its clinical use that are available so far to provide a perspective on the opportunities for clinical application of this cytokine.

MeSH Terms
Animals Cell Proliferation Clinical Trials as Topic Humans Interleukin-7/immunology,physiology,therapeutic use Lymphocyte Activation Lymphopenia/drug therapy,immunology Mice Neoplasms/drug therapy Receptors, Interleukin-7/genetics,metabolism Recombinant Proteins/therapeutic use Signal Transduction T-Lymphocyte Subsets/immunology,physiology T-Lymphocytes/immunology,physiology Virus Diseases/drug therapy
Chemicals
Interleukin-7 Receptors, Interleukin-7 Recombinant Proteins interleukin-7 receptor, alpha chain
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Mackall Crystal L
Immunology Section, Pediatric Oncology Branch, National Cancer Institute, Bethesda, Maryland, USA. [email protected]
Fry Terry J
Gress Ronald E
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Article Info
Journal
Nature reviews. Immunology
Abbr.
Nat Rev Immunol
ISSN
1474-1741
DOI
10.1038/nri2970
Email
[email protected]
Published
2011-05-00
Pages
330-42
Language
English
Region
England
NLM ID
101124169
PMCID
PMC7351348
Subset
IM
Grants
Intramural NIH HHS · Z01 BC011072 · United States
Intramural NIH HHS · Z01 SC006745 · United States
Intramural NIH HHS · Z01 SC010281 · United States
Intramural NIH HHS · Z01 SC010289 · United States
External Links
PubMed source DOI: 10.1038/nri2970 PMC Full Text View journal details
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