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PMID: 2152825 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Relationship of the env genes and the endonuclease domain of the pol genes of simian foamy virus type 1 and human foamy virus.

Journal of virology ·Vol. 64 ·No. 1 ·1990-01-00 ·Pages 406-10

Mergia A, Shaw KE, Lackner JE, Luciw PA

Abstract

We have molecularly cloned and sequenced a portion of the simian foamy virus type 1 (SFV-1); open reading frames representing the endonuclease domain of the polymerase (pol) and the envelope (env) genes were identified by comparison with the human foamy virus (HFV). Unlike the HFV genomic organization, the SFV-1 pol gene overlaps the env gene; thus, the open reading frames reported for HFV between pol and env is not present in SFV-1. Comparisons of predicted amino acid sequences of HFV and SFV-1 reveal that the endonuclease domains of the pol genes are about 84% related. The region predicted to encode the SFV-1 extracellular env domain is 569 codons; SFV-1 and HFV have 64% amino acid similarity in this env domain. The predicted hydrophobic transmembrane env proteins of both HFV and SFV-1 show about 73% similarity. A total of 16 potential glycosylation sites are found in SFV-1 env, and 15 are found in HFV; 11 are shared. SFV-1 has 25 cysteine residues, and HFV has 23 residues; all 23 cysteine residues of HFV are conserved in SFV-1. This sequence analysis reveals that the human and simian foamy viruses are highly related.

MeSH Terms
Amino Acid Sequence Animals Base Sequence Gene Products, env/genetics Gene Products, pol/genetics Genes, Viral Humans Molecular Sequence Data Retroviridae/genetics Sequence Homology, Nucleic Acid Species Specificity Spumavirus/genetics Viral Structural Proteins/genetics
Chemicals
Gene Products, env Gene Products, pol Viral Structural Proteins
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Mergia A
Department of Pathology, School of Medicine, University of California, Davis 95616.
Shaw K E
Lackner J E
Luciw P A
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.64.1.406-410.1990
Published
1990-01-00
Pages
406-10
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC249116
Subset
IM
Grants
NIAID NIH HHS · AI27732 · United States
Databases
GENBANK
M33561
External Links
PubMed source DOI: 10.1128/JVI.64.1.406-410.1990 PMC Full Text View journal details
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