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PMID: 2154612 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Soluble recombinant CR2 (CD21) inhibits Epstein-Barr virus infection.

Journal of virology ·Vol. 64 ·No. 3 ·1990-03-00 ·Pages 1348-52

Nemerow GR, Mullen JJ, Dickson PW, Cooper NR

Abstract

Epstein-Barr virus (EBV), an oncogenic herpesvirus of humans, displays selective tropism for B lymphocytes and epithelial cells. EBV tropism is thought to be determined in part by a unique host cell receptor termed CR2 (CD21). Although previous studies have demonstrated that CR2 mediates EBV binding to B cells, its role in initiating EBV infection and B-cell transformation is less certain. In the studies reported here, soluble recombinant CR2 was shown to cause substantial inhibition of EBV infection of B cells in vitro, indicating that CR2 binding initiates EBV infection. Soluble CR2 may represent a therapeutic agent for acute and chronic EBV infections in humans.

MeSH Terms
Antigens, CD Antigens, Differentiation, B-Lymphocyte/genetics Antiviral Agents B-Lymphocytes/immunology Base Sequence Genetic Vectors Herpesvirus 4, Human/immunology Humans Molecular Sequence Data Oligonucleotide Probes Receptors, Complement/genetics Receptors, Complement 3d Receptors, Virus/immunology,physiology Recombinant Proteins/pharmacology
Chemicals
Antigens, CD Antigens, Differentiation, B-Lymphocyte Antiviral Agents Oligonucleotide Probes Receptors, Complement Receptors, Complement 3d Receptors, Virus Recombinant Proteins
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Nemerow G R
Department of Immunology, Research Institute of Scripps Clinic, La Jolla, California 92037.
Mullen J J
Dickson P W
Cooper N R
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.64.3.1348-1352.1990
Published
1990-03-00
Pages
1348-52
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC249254
Subset
IM
Grants
NIAID NIH HHS · AI17354 · United States
NCI NIH HHS · CA14692 · United States
NCI NIH HHS · CA36204 · United States
External Links
PubMed source DOI: 10.1128/JVI.64.3.1348-1352.1990 PMC Full Text View journal details
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