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PMID: 21547229 Published · epublish English Journal Article

Neuroimaging measures as endophenotypes in Alzheimer's disease.

International journal of Alzheimer's disease ·Vol. 2011 ·2011-03-31 ·Pages 490140

Braskie MN, Ringman JM, Thompson PM

Abstract

Late onset Alzheimer's disease (AD) is moderately to highly heritable. Apolipoprotein E allele ε4 (APOE4) has been replicated consistently as an AD risk factor over many studies, and recently confirmed variants in other genes such as CLU, CR1, and PICALM each increase the lifetime risk of AD. However, much of the heritability of AD remains unexplained. AD is a complex disease that is diagnosed largely through neuropsychological testing, though neuroimaging measures may be more sensitive for detecting the incipient disease stages. Difficulties in early diagnosis and variable environmental contributions to the disease can obscure genetic relationships in traditional case-control genetic studies. Neuroimaging measures may be used as endophenotypes for AD, offering a reliable, objective tool to search for possible genetic risk factors. Imaging measures might also clarify the specific mechanisms by which proposed risk factors influence the brain.

Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Braskie Meredith N
Laboratory of Neuro Imaging, Department of Neurology, UCLA School of Medicine, 635 Charles Young Drive South, Suite 225, Los Angeles, CA 90095, USA.
Ringman John M
Thompson Paul M
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Article Info
Journal
International journal of Alzheimer's disease
Abbr.
Int J Alzheimers Dis
ISSN
2090-0252
DOI
10.4061/2011/490140
Published
2011-03-31
Epub
2011-00-31
Pages
490140
Language
English
Region
United States
NLM ID
101525141
PMCID
PMC3087508
External Links
PubMed source DOI: 10.4061/2011/490140 PMC Full Text
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