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PMID: 2156778 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Human CD28 and CTLA-4 Ig superfamily genes are located on chromosome 2 at bands q33-q34.

Immunogenetics ·Vol. 31 ·No. 3 ·1990-00-00 ·Pages 198-201

Lafage-Pochitaloff M, Costello R, Couez D, Simonetti J, Mannoni P, Mawas C, Olive D

Abstract

CD28 is a cell surface molecule present on most peripheral T cells which has been implied in the amplification of the T-cell response in vitro. Using in situ hybridization on human prometaphase cells, we have found that the human CD28 gene maps to chromosome 2 at bands q33-q34, as shown previously for the CTLA-4 gene. CD28 and CTLA-4 are both members of the Ig superfamily, where they define a subgroup of membrane-bound single V domains. Their chromosomal proximity and their close structural relationship suggest that these two genes could be the result of the duplication of a common evolutionary precursor and may share some functional properties.

MeSH Terms
Antigens, CD/genetics Antigens, Differentiation, T-Lymphocyte/genetics Autoradiography CD28 Antigens Chromosome Mapping Chromosomes, Human, Pair 2/analysis Humans Male Multigene Family Nucleic Acid Hybridization
Chemicals
Antigens, CD Antigens, Differentiation, T-Lymphocyte CD28 Antigens
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Lafage-Pochitaloff M
INSERM U. 119, Institut Paoli-Calmettes, Marseille, France.
Costello R
Couez D
Simonetti J
Mannoni P
Mawas C
Olive D
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Article Info
Journal
Immunogenetics
Abbr.
Immunogenetics
ISSN
0093-7711
DOI
10.1007/BF00211556
Published
1990-00-00
Pages
198-201
Language
English
Region
United States
NLM ID
0420404
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00211556 View journal details
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