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PMID: 2164640 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

The cytomegalovirus enhancer: a pan-active control element in transgenic mice.

Molecular and cellular biology ·Vol. 10 ·No. 8 ·1990-08-00 ·Pages 4406-11

Schmidt EV, Christoph G, Zeller R, Leder P

Abstract

In an effort to identify widely active positive regulatory elements, we have examined the action of the cytomegalovirus enhancer-promoter in transgenic mice. These elements activated expression in 24 of 28 tissues tested. The greatest expression was observed in the heart, kidney, brain, and testis. Maximum expression further localized to specific cells within the heart and kidney.

MeSH Terms
Animals Cytomegalovirus/genetics Enhancer Elements, Genetic Gene Expression Regulation, Viral Heart/microbiology Kidney/microbiology Male Mice Mice, Transgenic Organ Specificity Promoter Regions, Genetic RNA Probes Restriction Mapping Transcription, Genetic
Chemicals
RNA Probes
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Schmidt E V
Department of Genetics, Harvard Medical School, Howard Hughes Medical Institute, Boston, Massachusetts 02115.
Christoph G
Zeller R
Leder P
References (17)
17 references, click to expand
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Article Info
Journal
Molecular and cellular biology
Abbr.
Mol Cell Biol
ISSN
0270-7306
DOI
10.1128/mcb.10.8.4406-4411.1990
Published
1990-08-00
Pages
4406-11
Language
English
Region
United States
NLM ID
8109087
PMCID
PMC361001
Subset
IM
External Links
PubMed source DOI: 10.1128/mcb.10.8.4406-4411.1990 PMC Full Text View journal details
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