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PMID: 2165604 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

A distinctive family of embryonic protein-tyrosine kinase receptors.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 87 ·No. 15 ·1990-08-00 ·Pages 5812-6

Pasquale EB

Abstract

Two closely related protein-tyrosine kinases with the characteristics of growth factor receptors were identified by screening a chicken embryo cDNA expression library with anti-phosphotyrosine antibodies and were designated Cek2 and Cek3 (chicken embryo kinases 2 and 3). Cek2 and Cek3 are structurally related to Cek1, a chicken basic fibroblast growth factor receptor, and presumably represent receptors for basic fibroblast growth factor-related molecules. The identification of Cek2 and Cek3 establishes the existence of a family of protein-tyrosine kinases that includes Cek1 and that is likely to be implicated in the control of developmental processes. Among protein-tyrosine kinases, this family of receptors, which may include other as yet unknown members, is most closely related to the protooncogene product Ret and the platelet-derived growth factor receptor family.

MeSH Terms
Amino Acid Sequence Animals Biological Evolution Chick Embryo Gene Library Growth Substances/metabolism Isoenzymes/genetics Molecular Sequence Data Multigene Family Protein-Tyrosine Kinases/genetics RNA, Messenger/genetics Receptors, Cell Surface/genetics Sequence Homology, Nucleic Acid
Chemicals
Growth Substances Isoenzymes RNA, Messenger Receptors, Cell Surface Protein-Tyrosine Kinases
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Pasquale E B
Department of Biology, University of California, San Diego, La Jolla 92093.
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35 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.87.15.5812
Published
1990-08-00
Pages
5812-6
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC54418
Subset
IM
Grants
NIGMS NIH HHS · GM15971 · United States
NICHD NIH HHS · HD26351 · United States
Databases
GENBANK
M24637, M35195, M35196
External Links
PubMed source DOI: 10.1073/pnas.87.15.5812 PMC Full Text View journal details
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