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PMID: 21663789 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

The human brain in a dish: the promise of iPSC-derived neurons.

Cell ·Vol. 145 ·No. 6 ·2011-06-10 ·Pages 831-4

Dolmetsch R, Geschwind DH

Abstract

Induced pluripotent stem cell-derived neurons from patients promise to fill an important niche between studies in humans and model organisms in deciphering mechanisms and identifying therapeutic avenues for neurologic and psychiatric diseases. Recent work begins to tap this potential and also highlights challenges that must be overcome to be fully realized.

MeSH Terms
Animals Brain/cytology Brain Diseases/pathology Humans Induced Pluripotent Stem Cells/cytology Mental Disorders/pathology Neurons/cytology,pathology
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Dolmetsch Ricardo
Department of Neurobiology, Fairchild Research Building, Room D227, Stanford University, Stanford, CA 94305, USA. [email protected]
Geschwind Daniel H
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Article Info
Journal
Cell
Abbr.
Cell
ISSN
1097-4172
DOI
10.1016/j.cell.2011.05.034
Email
[email protected]
Published
2011-06-10
Pages
831-4
Language
English
Region
United States
NLM ID
0413066
PMCID
PMC3691069
Subset
IM
Grants
NIMH NIH HHS · DP1 MH099904 · United States
NIMH NIH HHS · R01 MH081754 · United States
External Links
PubMed source DOI: 10.1016/j.cell.2011.05.034 PMC Full Text View journal details
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