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PMID: 21677746 Published · epublish English Journal Article Research Support, Non-U.S. Gov't Review

Intestinal homeostasis and its breakdown in inflammatory bowel disease.

Nature ·Vol. 474 ·No. 7351 ·2011-06-15 ·Pages 298-306

Maloy KJ, Powrie F

Abstract

Intestinal homeostasis depends on complex interactions between the microbiota, the intestinal epithelium and the host immune system. Diverse regulatory mechanisms cooperate to maintain intestinal homeostasis, and a breakdown in these pathways may precipitate the chronic inflammatory pathology found in inflammatory bowel disease. It is now evident that immune effector modules that drive intestinal inflammation are conserved across innate and adaptive leukocytes and can be controlled by host regulatory cells. Recent evidence suggests that several factors may tip the balance between homeostasis and intestinal inflammation, presenting future challenges for the development of new therapies for inflammatory bowel disease.

MeSH Terms
Animals Autophagy Epithelium/metabolism,pathology,physiopathology Homeostasis Humans Inflammation/immunology,pathology Inflammatory Bowel Diseases/genetics,immunology,pathology,physiopathology Intestinal Mucosa/cytology,immunology,metabolism,pathology,physiopathology Intestines/immunology,microbiology,physiopathology Models, Biological Receptors, Pattern Recognition/metabolism
Chemicals
Receptors, Pattern Recognition
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Maloy Kevin J
Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK. [email protected]
Powrie Fiona
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Article Info
Journal
Nature
Abbr.
Nature
ISSN
1476-4687
DOI
10.1038/nature10208
Email
[email protected]
Published
2011-06-15
Epub
2011-00-15
Pages
298-306
Language
English
Region
England
NLM ID
0410462
Subset
IM
Grants
Wellcome Trust · 086354 · United Kingdom
Cancer Research UK · United Kingdom
External Links
PubMed source DOI: 10.1038/nature10208 View journal details
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