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PMID: 20559326 Published · ppublish English Journal Article Review

Innate IL-17-producing cells: the sentinels of the immune system.

Nature reviews. Immunology ·Vol. 10 ·No. 7 ·2010-07-00 ·Pages 479-89

Cua DJ, Tato CM

Abstract

The cytokine interleukin-17 (IL-17) has received considerable attention since the discovery of a distinct CD4(+) T helper (T(H)) cell subset that produces it, known as the T(H)17 cell subset. Despite the fact that most of the recent literature describes IL-17 as a T cell-secreted cytokine, much of the IL-17 released during an inflammatory response is produced by innate immune cells. In this Review, we explore the many innate immune cell populations that are an early source of IL-17 in response to stress, injury or pathogens. These early sources have been shown to have a central role in the initiation of IL-17-dependent immune responses, even before the first CD4(+)T cell sees its cognate antigen and initiates the T(H)17 cell developmental programme.

MeSH Terms
Animals Autoimmunity Cytokines/metabolism Humans Immunity, Innate Infections/immunology Interleukin-17/biosynthesis Killer Cells, Natural/immunology Lymphocyte Activation Mice Models, Immunological Neutrophils/immunology Nuclear Receptor Subfamily 1, Group F, Member 3/metabolism Paneth Cells/immunology Receptors, Antigen, T-Cell, gamma-delta/metabolism Receptors, Aryl Hydrocarbon/metabolism Signal Transduction/immunology T-Lymphocyte Subsets/immunology T-Lymphocytes, Helper-Inducer/immunology
Chemicals
Cytokines Interleukin-17 Nuclear Receptor Subfamily 1, Group F, Member 3 Receptors, Antigen, T-Cell, gamma-delta Receptors, Aryl Hydrocarbon
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Cua Daniel J
Merck Research Laboratories, DNAX Discovery Research, 901 California Avenue, Palo Alto, CA 94304, USA. [email protected]
Tato Cristina M
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Article Info
Journal
Nature reviews. Immunology
Abbr.
Nat Rev Immunol
ISSN
1474-1741
DOI
10.1038/nri2800
Email
[email protected]
Published
2010-07-00
Epub
2010-00-18
Pages
479-89
Language
English
Region
England
NLM ID
101124169
Subset
IM
Corrections
ErratumIn
-
ErratumIn
-
External Links
PubMed source DOI: 10.1038/nri2800 View journal details
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