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PMID: 21773009 Published · ppublish English Journal Article

Genetics of childhood obesity.

Journal of obesity ·Vol. 2011 ·2011-00-00 ·Pages 845148

Zhao J, Grant SF

Abstract

Obesity is a major health problem and an immense economic burden on the health care systems both in the United States and the rest of the world. The prevalence of obesity in children and adults in the United States has increased dramatically over the past decade. Besides environmental factors, genetic factors are known to play an important role in the pathogenesis of obesity. Genome-wide association studies (GWAS) have revealed strongly associated genomic variants associated with most common disorders; indeed there is general consensus on these findings from generally positive replication outcomes by independent groups. To date, there have been only a few GWAS-related reports for childhood obesity specifically, with studies primarily uncovering loci in the adult setting instead. It is clear that a number of loci previously reported from GWAS analyses of adult BMI and/or obesity also play a role in childhood obesity.

Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Zhao Jianhua
Division of Human Genetics, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Grant Struan F A
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Article Info
Journal
Journal of obesity
Abbr.
J Obes
ISSN
2090-0716
DOI
10.1155/2011/845148
Published
2011-00-00
Epub
2011-00-26
Pages
845148
Language
English
Region
United States
NLM ID
101526295
PMCID
PMC3136227
External Links
PubMed source DOI: 10.1155/2011/845148 PMC Full Text View journal details
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