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PMID: 21785456 Published · epublish English Journal Article Research Support, Non-U.S. Gov't Review

Neutrophils in the activation and regulation of innate and adaptive immunity.

Nature reviews. Immunology ·Vol. 11 ·No. 8 ·2011-07-25 ·Pages 519-31

Mantovani A, Cassatella MA, Costantini C, Jaillon S

Abstract

Neutrophils have long been viewed as the final effector cells of an acute inflammatory response, with a primary role in the clearance of extracellular pathogens. However, more recent evidence has extended the functions of these cells. The newly discovered repertoire of effector molecules in the neutrophil armamentarium includes a broad array of cytokines, extracellular traps and effector molecules of the humoral arm of the innate immune system. In addition, neutrophils are involved in the activation, regulation and effector functions of innate and adaptive immune cells. Accordingly, neutrophils have a crucial role in the pathogenesis of a broad range of diseases, including infections caused by intracellular pathogens, autoimmunity, chronic inflammation and cancer.

MeSH Terms
Adaptive Immunity/immunology Animals Disease/etiology Humans Immunity, Innate/immunology Neutrophils/cytology,immunology
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Mantovani Alberto
Istituto Clinico Humanitas IRCCS, via Manzoni 56, 20089 Rozzano, Italy. [email protected]
Cassatella Marco A
Costantini Claudio
Jaillon Sébastien
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Article Info
Journal
Nature reviews. Immunology
Abbr.
Nat Rev Immunol
ISSN
1474-1741
DOI
10.1038/nri3024
Email
[email protected]
Published
2011-07-25
Epub
2011-00-25
Pages
519-31
Language
English
Region
England
NLM ID
101124169
Subset
IM
External Links
PubMed source DOI: 10.1038/nri3024 View journal details
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