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PMID: 21808287 Published · epublish English Journal Article Research Support, Non-U.S. Gov't Review

What's new in our understanding of the role of adipokines in rheumatic diseases?

Nature reviews. Rheumatology ·Vol. 7 ·No. 9 ·2011-08-02 ·Pages 528-36

Gómez R, Conde J, Scotece M, Gómez-Reino JJ, Lago F, Gualillo O

Abstract

Important advances in our understanding of the relationships between adipokines, inflammation and the immune response have been achieved in the past 10 years. White adipose tissue has emerged as a highly dynamic organ that releases a plethora of immune and inflammatory mediators that are involved in numerous diseases, including not only rheumatic diseases such as rheumatoid arthritis, osteoarthritis and systemic lupus erythematosus, but also cardiovascular and metabolic complications that are frequently observed in rheumatic diseases. Our rapidly growing knowledge of adipokine biology is revealing the complexity of these amazing proteins, thereby redefining white adipose tissue as a key element of the inflammatory and immune response in rheumatic diseases. Adipokines exert potent modulatory actions on target tissues and cells involved in rheumatic disease, including cartilage, synovium, bone and various immune cells. In this Review, we describe the most recent advances in adipokine research in the context of rheumatic diseases, focusing primarily on leptin, adiponectin, visfatin and resistin, and also the potential role of newly identified adipokines such as chemerin, lipocalin 2 and serum amyloid A3.

MeSH Terms
Adipokines/physiology Adiponectin/metabolism Animals Disease Models, Animal Humans Leptin/metabolism Rheumatic Diseases/etiology,metabolism,physiopathology
Chemicals
Adipokines Adiponectin Leptin
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Gómez Rodolfo
SERGAS, Santiago University Clinical Hospital, Research Laboratory, Institute of Medical Research, Travesía de la Choupana, Santiago de Compostela, Spain.
Conde Javier
Scotece Morena
Gómez-Reino Juan Jesus
Lago Francisca
Gualillo Oreste
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Article Info
Journal
Nature reviews. Rheumatology
Abbr.
Nat Rev Rheumatol
ISSN
1759-4804
DOI
10.1038/nrrheum.2011.107
Published
2011-08-02
Epub
2011-00-02
Pages
528-36
Language
English
Region
United States
NLM ID
101500080
Subset
IM
External Links
PubMed source DOI: 10.1038/nrrheum.2011.107 View journal details
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