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PMID: 21885598 Published · epublish English Journal Article Research Support, N.I.H., Extramural Review

Integrins in cell migration.

Cold Spring Harbor perspectives in biology ·Vol. 3 ·No. 9 ·2011-09-01 ·Pages a005074

Huttenlocher A, Horwitz AR

Abstract

Integrin-based adhesion has served as a model for studying the central role of adhesion in migration. In this article, we outline modes of migration, both integrin-dependent and -independent in vitro and in vivo. We next discuss the roles of adhesion contacts as signaling centers and linkages between the ECM and actin that allows adhesions to serve as traction sites. This includes signaling complexes that regulate migration and the interplay among adhesion, signaling, and pliability of the substratum. Finally, we address mechanisms of adhesion assembly and disassembly and the role of adhesion in cellular polarity.

MeSH Terms
Cell Movement/physiology Cell Polarity/physiology Focal Adhesions/physiology Integrins/metabolism Models, Biological Signal Transduction/physiology
Chemicals
Integrins
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Huttenlocher Anna
Departments of Pediatrics and Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, Wsconsin 53706, USA.
Horwitz Alan Rick
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Article Info
Journal
Cold Spring Harbor perspectives in biology
Abbr.
Cold Spring Harb Perspect Biol
ISSN
1943-0264
DOI
10.1101/cshperspect.a005074
Published
2011-09-01
Epub
2011-00-01
Pages
a005074
Language
English
Region
United States
NLM ID
101513680
PMCID
PMC3181029
Subset
IM
Grants
NCI NIH HHS · R01 CA085862 · United States
NIGMS NIH HHS · U54 GM064346 · United States
NIGMS NIH HHS · GM23244 · United States
NCI NIH HHS · CA085862-08 · United States
NIGMS NIH HHS · R37 GM023244 · United States
NIGMS NIH HHS · U54-GM064346 · United States
NIGMS NIH HHS · R01 GM023244 · United States
External Links
PubMed source DOI: 10.1101/cshperspect.a005074 PMC Full Text View journal details
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