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PMID: 21441590 Published · epublish English Journal Article Research Support, N.I.H., Extramural Research Support, N.I.H., Intramural Research Support, Non-U.S. Gov't Review

Molecular architecture and function of matrix adhesions.

Cold Spring Harbor perspectives in biology ·Vol. 3 ·No. 5 ·2011-05-01

Geiger B, Yamada KM

Abstract

Cell adhesions mediate important bidirectional interactions between cells and the extracellular matrix. They provide an interactive interface between the extracellular chemical and physical environment and the cellular scaffolding and signaling machinery. This dynamic, reciprocal regulation of intracellular processes and the matrix is mediated by membrane receptors such as the integrins, as well as many other components that comprise the adhesome. Adhesome constituents assemble themselves into different types of cell adhesion structures that vary in molecular complexity and change over time. These cell adhesions play crucial roles in cell migration, proliferation, and determination of cell fate.

MeSH Terms
Biomechanical Phenomena Cell Adhesion/physiology Cell Movement Cell Proliferation Extracellular Matrix/chemistry,physiology,ultrastructure Humans Integrins/metabolism,physiology Models, Biological Models, Molecular Receptors, Cell Surface/metabolism,physiology Signal Transduction
Chemicals
Integrins Receptors, Cell Surface
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Geiger Benjamin
Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel. [email protected]
Yamada Kenneth M
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Article Info
Journal
Cold Spring Harbor perspectives in biology
Abbr.
Cold Spring Harb Perspect Biol
ISSN
1943-0264
DOI
10.1101/cshperspect.a005033
Email
[email protected]
Published
2011-05-01
Epub
2011-00-01
Language
English
Region
United States
NLM ID
101513680
PMCID
PMC3101841
Subset
IM
Grants
NEI NIH HHS · PN2 EY016586 · United States
NIGMS NIH HHS · U54GM64346 · United States
Intramural NIH HHS · ZIA DE000524-21 · United States
NIGMS NIH HHS · U54 GM064346 · United States
Intramural NIH HHS · ZIA DE000718-05 · United States
External Links
PubMed source DOI: 10.1101/cshperspect.a005033 PMC Full Text View journal details
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