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PMID: 21960727 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Imaging: guiding the clinical translation of cardiac stem cell therapy.

Circulation research ·Vol. 109 ·No. 8 ·2011-09-30 ·Pages 962-79

Nguyen PK, Lan F, Wang Y, Wu JC

Abstract

Stem cells have been touted as the holy grail of medical therapy, with promises to regenerate cardiac tissue, but it appears the jury is still out on this novel therapy. Using advanced imaging technology, scientists have discovered that these cells do not survive nor engraft long-term. In addition, only marginal benefit has been observed in large-animal studies and human trials. However, all is not lost. Further application of advanced imaging technology will help scientists unravel the mysteries of stem cell therapy and address the clinical hurdles facing its routine implementation. In this review, we will discuss how advanced imaging technology will help investigators better define the optimal delivery method, improve survival and engraftment, and evaluate efficacy and safety. Insights gained from this review may direct the development of future preclinical investigations and clinical trials.

MeSH Terms
Animals Cell Differentiation/physiology Cell Survival/physiology Diagnostic Imaging/trends Heart Diseases/diagnosis,surgery Humans Myocytes, Cardiac/cytology,physiology Stem Cell Transplantation/trends Translational Research, Biomedical/trends
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Nguyen Patricia K
Department of Medicine, Division of Cardiology, Molecular Imaging Program at Stanford, CA 94305, USA.
Lan Feng
Wang Yongming
Wu Joseph C
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Article Info
Journal
Circulation research
Abbr.
Circ Res
ISSN
1524-4571
DOI
10.1161/CIRCRESAHA.111.242909
Published
2011-09-30
Pages
962-79
Language
English
Region
United States
NLM ID
0047103
PMCID
PMC3206967
Subset
IM
Grants
NHLBI NIH HHS · R33 HL089027-05 · United States
NIBIB NIH HHS · R01 EB009689 · United States
NIBIB NIH HHS · R01 EB009689-03 · United States
NHLBI NIH HHS · RC1 HL099117-02 · United States
NHLBI NIH HHS · R33 HL089027 · United States
NHLBI NIH HHS · HL099117 · United States
PHS HHS · E8009689 · United States
NHLBI NIH HHS · HL089027 · United States
NHLBI NIH HHS · RC1 HL099117 · United States
External Links
PubMed source DOI: 10.1161/CIRCRESAHA.111.242909 PMC Full Text View journal details
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