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PMID: 22169974 Published · epublish English Journal Article Research Support, Non-U.S. Gov't Review

Epithelial cell polarity, stem cells and cancer.

Nature reviews. Cancer ·Vol. 12 ·No. 1 ·2011-12-15 ·Pages 23-38

Martin-Belmonte F, Perez-Moreno M

Abstract

After years of extensive scientific discovery much has been learned about the networks that regulate epithelial homeostasis. Loss of expression or functional activity of cell adhesion and cell polarity proteins (including the PAR, crumbs (CRB) and scribble (SCRIB) complexes) is intricately related to advanced stages of tumour progression and invasiveness. But the key roles of these proteins in crosstalk with the Hippo and liver kinase B1 (LKB1)-AMPK pathways and in epithelial function and proliferation indicate that they may also be associated with the early stages of tumorigenesis. For example, deregulation of adhesion and polarity proteins can cause misoriented cell divisions and increased self-renewal of adult epithelial stem cells. In this Review, we highlight some advances in the understanding of how loss of epithelial cell polarity contributes to tumorigenesis.

MeSH Terms
AMP-Activated Protein Kinase Kinases Adaptor Proteins, Signal Transducing Animals Cell Cycle Proteins/physiology Cell Polarity Drosophila Proteins/physiology Epithelial Cells/physiology Epithelial-Mesenchymal Transition Humans Intracellular Signaling Peptides and Proteins/physiology Membrane Proteins/physiology Neoplasms/etiology Protein Serine-Threonine Kinases/physiology Protein Structure, Tertiary Signal Transduction Stem Cells/physiology Tumor Suppressor Proteins/physiology
Chemicals
Adaptor Proteins, Signal Transducing Cell Cycle Proteins Drosophila Proteins Intracellular Signaling Peptides and Proteins Membrane Proteins PARD3 protein, human SCRIB protein, human Tumor Suppressor Proteins Protein Serine-Threonine Kinases STK11 protein, human hpo protein, Drosophila AMP-Activated Protein Kinase Kinases
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Martin-Belmonte Fernando
Centro de Biología Molecular Severo Ochoa, Consejo Superior de Investigaciones Científicas, Madrid 28049, Spain. [email protected]
Perez-Moreno Mirna
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Article Info
Journal
Nature reviews. Cancer
Abbr.
Nat Rev Cancer
ISSN
1474-1768
DOI
10.1038/nrc3169
Email
[email protected]
Published
2011-12-15
Epub
2011-00-15
Pages
23-38
Language
English
Region
England
NLM ID
101124168
Subset
IM
External Links
PubMed source DOI: 10.1038/nrc3169 View journal details
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