Gene heterogeneity for tetracycline resistance in Staphylococcus spp.

Antimicrobial agents and chemotherapy ·Vol. 34 ·No. 8 ·1990-08-00 ·Pages 1611-4

Bismuth R, Zilhao R, Sakamoto H, Guesdon JL, Courvalin P

Abstract

Nucleotide sequences related to four tet genes were studied by hybridization in 183 clinical Staphylococcus isolates. tet(K) predominated in strains resistant only to tetracycline, while tet(M) was responsible for combined tetracycline and minocycline resistance. In strains harboring both genes, they contributed additively. tet(L) was detected in only five strains, and no hybridization was observed with tet(O).

MeSH Terms

DNA, Bacterial/analysis Genes, Bacterial Genetic Variation Minocycline/pharmacology Nucleic Acid Hybridization Staphylococcus/drug effects,genetics Tetracycline/pharmacology Tetracycline Resistance

Chemicals

DNA, Bacterial Tetracycline Minocycline

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Bismuth R

Unité des Agents Antibactériens, Institut Pasteur, Paris, France.

Zilhao R

Sakamoto H

Guesdon J L

Courvalin P

References (16)

16 references, click to expand

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Article Info

Journal

Antimicrobial agents and chemotherapy

Abbr.

Antimicrob Agents Chemother

ISSN

0066-4804

DOI

10.1128/AAC.34.8.1611

Published

1990-08-00

Pages

1611-4

Language

English

Region

United States

NLM ID

0315061

PMCID

PMC171885

Subset

External Links

PubMed source DOI: 10.1128/AAC.34.8.1611 PMC Full Text View journal details

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Gene heterogeneity for tetracycline resistance in Staphylococcus spp.

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