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PMID: 22249196 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Transcriptional control of glutamatergic differentiation during adult neurogenesis.

Cellular and molecular life sciences : CMLS ·Vol. 69 ·No. 13 ·2012-07-00 ·Pages 2125-34

Hodge RD, Kahoud RJ, Hevner RF

Abstract

Neurogenesis, the production of new neurons, occurs in two specialized niches in the adult brain, the subgranular zone (SGZ) of the dentate gyrus and the subventricular zone (SVZ) adjacent to the lateral ventricles. In the SGZ, neural stem cells (NSCs) give rise to glutamatergic granule neurons that integrate into the granule cell layer. In the SVZ, NSCs generate a more diverse cohort of new neurons, including GABAergic, dopaminergic, and glutamatergic neurons, all of which migrate to the olfactory bulb through the rostral migratory stream. In both adult neurogenic niches, specific transcription factors have been shown to direct fate specification and lineage commitment. This review summarizes current progress on the transcriptional control of glutamatergic neurogenesis in the SGZ and SVZ, highlighting commonalities as well as differences in their transcriptional programs. In particular, we focus on work from our laboratory and others indicating that precise, sequential expression of transcription factors regulates the progression from NSC to lineage-committed progenitor, and ultimately regulates the production and differentiation of adult-born glutamatergic neurons.

MeSH Terms
Adult Cell Differentiation/physiology Dentate Gyrus/physiology Gene Expression Regulation/genetics,physiology Humans Models, Biological Neural Stem Cells/cytology,metabolism Neurogenesis/physiology Receptors, Glutamate/metabolism Transcription Factors/metabolism
Chemicals
Receptors, Glutamate Transcription Factors
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Hodge Rebecca D
Department of Neurological Surgery, University of Washington, Seattle, WA, USA.
Kahoud Robert J
Hevner Robert F
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Article Info
Journal
Cellular and molecular life sciences : CMLS
Abbr.
Cell Mol Life Sci
ISSN
1420-9071
DOI
10.1007/s00018-011-0916-y
Published
2012-07-00
Epub
2012-00-17
Pages
2125-34
Language
English
Region
Switzerland
NLM ID
9705402
PMCID
PMC3360923
Subset
IM
Grants
NICHD NIH HHS · K12 HD000850 · United States
NIMH NIH HHS · R01 MH080766 · United States
NIMH NIH HHS · R01 MH080766-04 · United States
PHS HHS · R01 080766 · United States
External Links
PubMed source DOI: 10.1007/s00018-011-0916-y PMC Full Text View journal details
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