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PMID: 22269335 Published · epublish English Journal Article

What is complex about complex disorders?

Genome biology ·Vol. 13 ·No. 1 ·2012-01-23 ·Pages 237

Mitchell KJ

Abstract

Rather than being polygenic, complex disorders probably represent umbrella terms for collections of conditions caused by rare, recent mutations in any of a large number of different genes.

MeSH Terms
Genetic Association Studies Genetic Diseases, Inborn/genetics Genetic Predisposition to Disease Genetic Variation Genome-Wide Association Study Humans Multifactorial Inheritance Mutation Quantitative Trait, Heritable
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Mitchell Kevin J
Smurfit Institute of Genetics and Institute of Neuroscience, Trinity College Dublin, Dublin 2, Ireland. [email protected]
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Article Info
Journal
Genome biology
Abbr.
Genome Biol
ISSN
1474-760X
DOI
10.1186/gb-2012-13-1-237
Email
[email protected]
Published
2012-01-23
Epub
2012-00-23
Pages
237
Language
English
Region
England
NLM ID
100960660
PMCID
PMC3334577
Subset
IM
External Links
PubMed source DOI: 10.1186/gb-2012-13-1-237 PMC Full Text View journal details
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