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PMID: 22310894 Published · epublish English Journal Article Research Support, Non-U.S. Gov't Review

Human genetic susceptibility to infectious disease.

Nature reviews. Genetics ·Vol. 13 ·No. 3 ·2012-02-07 ·Pages 175-88

Chapman SJ, Hill AV

Abstract

Recent genome-wide studies have reported novel associations between common polymorphisms and susceptibility to many major infectious diseases in humans. In parallel, an increasing number of rare mutations underlying susceptibility to specific phenotypes of infectious disease have been described. Together, these developments have highlighted a key role for host genetic variation in determining the susceptibility to infectious disease. They have also provided insights into the genetic architecture of infectious disease susceptibility and identified immune molecules and pathways that are directly relevant to the human host defence.

MeSH Terms
Communicable Diseases/etiology Genetic Predisposition to Disease Genome, Human Humans Polymorphism, Genetic/genetics
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Chapman Stephen J
Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK. [email protected]
Hill Adrian V S
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Article Info
Journal
Nature reviews. Genetics
Abbr.
Nat Rev Genet
ISSN
1471-0064
DOI
10.1038/nrg3114
Email
[email protected]
Published
2012-02-07
Epub
2012-00-07
Pages
175-88
Language
English
Region
England
NLM ID
100962779
Subset
IM
Grants
Wellcome Trust · 090532 · United Kingdom
Wellcome Trust · 095540 · United Kingdom
Medical Research Council · G1001712 · United Kingdom
External Links
PubMed source DOI: 10.1038/nrg3114 View journal details
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