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PMID: 22457931 Published · ppublish English Journal Article

Anti H-2Dd alloreactivity mediated by herpes-simplex-virus specific cytotoxic H-2k T lymphocytes is associated with H-2Dk.

Immunogenetics ·Vol. 10 ·No. 4 ·1980-00-00 ·Pages 395-404

Pfizenmaier K, Jung H, Kurrle R, Röllinghoff M, Wagner H

Abstract

Herpes-simplex-virus (HSV) specific, H-2k-restricted, immune cytotoxic T lymphocytes also lyse noninfected H-2d target cells. Genetic mapping studies revealed that HSV-specific Dk-restricted CTL cross-react with allogeneic targets expressing Dd alloantigens. Cold target inhibition experiments indicate that only a minority of HSV-specific CTL mediate cross-reactive cytolysis. The data give an example of where the phenomenon of H-2-restricted versus nonrestricted responsiveness is not due to distinct subsets of T cells but solely depends on the antigenic determinants recognized.

MeSH Terms
Animals Cross Reactions/immunology Cytotoxicity, Immunologic Epitopes/immunology H-2 Antigens/genetics,immunology Histocompatibility Antigen H-2D Isoantibodies/immunology Mice Mice, Inbred BALB C Mice, Inbred CBA Simplexvirus/immunology T-Lymphocytes, Cytotoxic/immunology
Chemicals
Epitopes H-2 Antigens Histocompatibility Antigen H-2D Isoantibodies anti-H-2 antibodies
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Pfizenmaier K
Institut für Medizinische Mikrobiologie der Johannes-Gutenberg-Universität, Augustusplatz, D-6500 Mainz, Federal Republic of Germany.
Jung H
Kurrle R
Röllinghoff M
Wagner H
References (28)
28 references, click to expand
  1. Specificity of virus-immune effector T cells for H-2K or H-2D compatible interactions: implications for H-antigen diversity.
    Transplant Rev. 1976;29:89-124 PMID: 58463
  2. MHC-restricted cytotoxic T cells: studies on the biological role of polymorphic major transplantation antigens determining T-cell restriction-specificity, function, and responsiveness.
    Adv Immunol. 1979;27:51-177 PMID: 92183
  3. Sheep red blood cell-specific helper activity in rat thoracic duct lymphocyte populations positively selected for reactivity to specific strong histocompatibility alloantigens.
    J Exp Med. 1976 Mar 1;143(3):701-6 PMID: 55462
  4. The role of T cells in anti-herpes simplex virus immunity. I. Induction of antigen-specific cytotoxic T lymphocytes.
    J Immunol. 1977 Sep;119(3):939-44 PMID: 70478
  5. The influence of thymus H-2 antigens on the specificity of maturing killer and helper cells.
    Immunol Rev. 1978;42:3-19 PMID: 83702
  6. Killer cells reactive to altered-self antigens can also be alloreactive.
    Proc Natl Acad Sci U S A. 1977 May;74(5):2094-8 PMID: 141046
  7. Biological significance of alloreactivity: T cells stimulated by Sendai virus-coated syngeneic cells specifically lyse allogeneic target cells.
    Proc Natl Acad Sci U S A. 1978 Oct;75(10):5145-9 PMID: 217013
  8. Generation of effector cells from T cell subsets. I. Similar requirements for Lyt T cell subpopulations in the generation of alloreactive and H-2 restricted killer cells.
    Immunobiology. 1979 Aug;156(1-2):96-109 PMID: 232075
  9. Primary in vitro sensitization of virus specific cytotoxic T lymphocytes.
    Immunology. 1978 Apr;34(4):763-9 PMID: 82534
  10. Major histocompatibility complex restricted cell-mediated immunity.
    Adv Immunol. 1977;25:55-91 PMID: 76435
  11. Regulation of cellular and humoral immune responses by T-cell subclasses.
    Cold Spring Harb Symp Quant Biol. 1977;41 Pt 1:23-32 PMID: 302190
  12. The biologic significance of alloreactivity. The ontogeny of T-cell sets specific for alloantigens or modified self antigens.
    J Exp Med. 1978 Nov 1;148(5):1414-22 PMID: 214510
  13. The role of the major histocompatibility gene complex in murine cytotoxic T cell responses.
    Adv Cancer Res. 1980;31:77-124 PMID: 6157313
  14. Specultations on alternative pathways of T-lymphocyte response.
    Scand J Immunol. 1979;10(2):87-93 PMID: 91192
  15. Histocompatibility antigen-activated cytotoxic T lymphocytes. II. Estimates of the frequency and specificity of precursors.
    J Exp Med. 1977 Mar 1;145(3):508-22 PMID: 233899
  16. H-2-linked murine cytotoxic T cell responses specific for sendai virus-infected cells.
    Eur J Immunol. 1978 Dec;8(12):910-2 PMID: 83237
  17. Fine specificity of a continuously growing killer cell clone specific for H-Y antigen.
    Eur J Immunol. 1979 Aug;9(8):592-7 PMID: 91527
  18. Major histocompatibility complex-linked immune-responsiveness is acquired by lymphocytes of low-responder mice differentiating in thymus of high-responder mice.
    Proc Natl Acad Sci U S A. 1978 May;75(5):2439-42 PMID: 307765
  19. T-T-cell interactions during the vitro cytotoxic allograft responses. I. Soluble products from activated Lyl+ T cells trigger autonomously antigen-primed Ly23+ T cells to cell proliferation and cytolytic activity.
    J Exp Med. 1978 Dec 1;148(6):1523-38 PMID: 309919
  20. An estimation of the frequency of precursor cells which generate cytotoxic lymphocytes.
    J Exp Med. 1976 Jun 1;143(6):1562-7 PMID: 1083894
  21. Ir-genes in H-2 regulate generation of anti-viral cytotoxic T cells. Mapping to K or D and dominance of unresponsiveness.
    J Exp Med. 1978 Aug 1;148(2):592-606 PMID: 212503
  22. Cytotoxic T-cell responses in mice infected with influenza and vaccinia viruses vary in magnitude with H-2 genotype.
    J Exp Med. 1978 Aug 1;148(2):534-43 PMID: 100569
  23. Quantitative studies of the activation of cytotoxic lymphocyte precursor cells.
    Immunol Rev. 1977;35:38-58 PMID: 330390
  24. Selective response to H-Y antigen by F1 female mice sensitized to F1 male cells.
    J Exp Med. 1977 Aug 1;146(2):606-10 PMID: 69007
  25. Mapping of H-2 genes associated with T cell-mediated cytotoxic responses to SV40-tumour-associated specific antigens.
    Nature. 1978 Aug 17;274(5672):691-3 PMID: 209340
  26. Genetic control of cytolytic T-lymphocyte responses. I. Ir gene control of the specificity of cytolytic T-lymphocyte responses to trinitrophenyl-modified syngeneic cells.
    J Exp Med. 1978 Aug 1;148(2):341-50 PMID: 100567
  27. Responsiveness to HY antigen Ir gene complementation and target cell specificity.
    Immunol Rev. 1977;35:59-75 PMID: 70400
  28. Shared idiotypic determinants on B and T lymphocytes reactive against the same antigenic determinants. II. Determination of frequency and characteristics of idiotypic T and B lymphocytes in normal rats using direct visualization.
    J Exp Med. 1975 Nov 1;142(5):1218-30 PMID: 53259
Article Info
Journal
Immunogenetics
Abbr.
Immunogenetics
ISSN
0093-7711
DOI
10.1007/BF01561589
Published
1980-00-00
Pages
395-404
Language
English
Region
United States
NLM ID
0420404
Subset
IM
External Links
PubMed source DOI: 10.1007/BF01561589 View journal details
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