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PMID: 22513113 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Review

Bivalent histone modifications in early embryogenesis.

Current opinion in cell biology ·Vol. 24 ·No. 3 ·2012-06-00 ·Pages 374-86

Vastenhouw NL, Schier AF

Abstract

Histone modifications influence the interactions of transcriptional regulators with chromatin. Studies in embryos and embryonic stem (ES) cells have uncovered histone modification patterns that are diagnostic for different cell types and developmental stages. For example, bivalent domains consisting of regions of H3 lysine 27 trimethylation (H3K27me3) and H3 lysine 4 trimethylation (H3K4me3) mark lineage control genes in ES cells and zebrafish blastomeres. Such bivalent domains have garnered attention because the H3K27me3 mark might help repress lineage-regulatory genes during pluripotency while the H3K4me3 mark could poise genes for activation upon differentiation. Despite the prominence of the bivalent domain concept, studies in other model organisms have questioned its universal nature, and the function of bivalent domains has remained unclear. Histone marks are also associated with developmental regulatory genes in sperm. These observations have raised the possibility that specific histone modification patterns might persist from parent to offspring, but it is unclear whether histone marks are inherited or formed de novo. Here, we review the potential roles of H3K4me3 and H3K27me3 marks in embryos and ES cells and discuss how histone marks might be established, maintained and resolved during embryonic development.

MeSH Terms
Animals Cell Differentiation/genetics Chromatin/metabolism Embryonic Development/genetics,physiology Embryonic Stem Cells/cytology,metabolism Gene Expression Regulation Genes, Developmental Histones/chemistry,genetics,metabolism,physiology Humans Lysine/genetics,metabolism Zebrafish/embryology,genetics,metabolism
Chemicals
Chromatin Histones Lysine
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Vastenhouw Nadine L
Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA. [email protected]
Schier Alexander F
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Article Info
Journal
Current opinion in cell biology
Abbr.
Curr Opin Cell Biol
ISSN
1879-0410
DOI
10.1016/j.ceb.2012.03.009
Email
[email protected]
Published
2012-06-00
Epub
2012-00-17
Pages
374-86
Language
English
Region
England
NLM ID
8913428
PMCID
PMC3372573
Subset
IM
Grants
NICHD NIH HHS · K99 HD067220 · United States
NIGMS NIH HHS · 5R01 GM056211 · United States
NICHD NIH HHS · R21 HD072733 · United States
NIGMS NIH HHS · R01 GM056211 · United States
NICHD NIH HHS · 1K99HD067220-01 · United States
External Links
PubMed source DOI: 10.1016/j.ceb.2012.03.009 PMC Full Text View journal details
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