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PMID: 22844258 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Genetic variants in REC8, RNF212, and PRDM9 influence male recombination in cattle.

PLoS genetics ·Vol. 8 ·No. 7 ·2012-00-00 ·Pages e1002854

Sandor C, Li W, Coppieters W, Druet T, Charlier C, Georges M

Abstract

We use >250,000 cross-over events identified in >10,000 bovine sperm cells to perform an extensive characterization of meiotic recombination in male cattle. We map Quantitative Trait Loci (QTL) influencing genome-wide recombination rate, genome-wide hotspot usage, and locus-specific recombination rate. We fine-map three QTL and present strong evidence that genetic variants in REC8 and RNF212 influence genome-wide recombination rate, while genetic variants in PRDM9 influence genome-wide hotspot usage.

MeSH Terms
Animals Cattle Cell Cycle Proteins/genetics Chromosome Mapping Crossing Over, Genetic Genetic Linkage Genome Histone-Lysine N-Methyltransferase/genetics Homologous Recombination/genetics Humans Ligases Male Miosis/genetics Pedigree Polymorphism, Single Nucleotide Quantitative Trait Loci/genetics Sequence Homology, Amino Acid Sperm Count Spermatozoa/cytology Ubiquitin-Protein Ligases/genetics
Chemicals
Cell Cycle Proteins REC8 protein, human Histone-Lysine N-Methyltransferase PRDM9 protein, human Ubiquitin-Protein Ligases Ligases RNF212 protein, human
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Sandor Cynthia
Unit of Animal Genomics, GIGA-R and Faculty of Veterinary Medicine, University of Liège, Liège, Belgium.
Li Wanbo
Coppieters Wouter
Druet Tom
Charlier Carole
Georges Michel
Conflict of Interest

The authors have declared that no competing interests exist.

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Article Info
Journal
PLoS genetics
Abbr.
PLoS Genet
ISSN
1553-7404
DOI
10.1371/journal.pgen.1002854
Published
2012-00-00
Epub
2012-00-26
Pages
e1002854
Language
English
Region
United States
NLM ID
101239074
PMCID
PMC3406008
Subset
IM
External Links
PubMed source DOI: 10.1371/journal.pgen.1002854 PMC Full Text View journal details
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