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PMID: 22863739 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Mesenchymal stem cells in tumor development: emerging roles and concepts.

Cell adhesion & migration ·Vol. 6 ·No. 3 ·2012-00-00 ·Pages 220-30

Cuiffo BG, Karnoub AE

Abstract

Mesenchymal stem cells (MSCs) are multipotent progenitor cells that participate in the structural and functional maintenance of connective tissues under normal homeostasis. They also act as trophic mediators during tissue repair, generating bioactive molecules that help in tissue regeneration following injury. MSCs serve comparable roles in cases of malignancy and are becoming increasingly appreciated as critical components of the tumor microenvironment. MSCs home to developing tumors with great affinity, where they exacerbate cancer cell proliferation, motility, invasion and metastasis, foster angiogenesis, promote tumor desmoplasia and suppress anti-tumor immune responses. These multifaceted roles emerge as a product of reciprocal interactions occurring between MSCs and cancer cells and serve to alter the tumor milieu, setting into motion a dynamic co-evolution of both tumor and stromal tissues that favors tumor progression. Here, we summarize our current knowledge about the involvement of MSCs in cancer pathogenesis and review accumulating evidence that have placed them at the center of the pro-malignant tumor stroma.

MeSH Terms
Animals Cell Communication Cell Movement Cell Transformation, Neoplastic/pathology Humans Mesenchymal Stem Cells/pathology Neoplasms/immunology,pathology Neoplastic Stem Cells/pathology Tumor Microenvironment
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Cuiffo Benjamin G
Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Karnoub Antoine E
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Article Info
Journal
Cell adhesion & migration
Abbr.
Cell Adh Migr
ISSN
1933-6926
DOI
10.4161/cam.20875
Published
2012-00-00
Epub
2012-00-01
Pages
220-30
Language
English
Region
United States
NLM ID
101469464
PMCID
PMC3427236
Subset
IM
External Links
PubMed source DOI: 10.4161/cam.20875 PMC Full Text View journal details
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