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PMID: 2295881 Published · ppublish English Comparative Study Journal Article Research Support, U.S. Gov't, P.H.S.

Surprisingly uneven distribution of the T cell receptor V beta repertoire in wild mice.

The Journal of experimental medicine ·Vol. 171 ·No. 1 ·1990-01-01 ·Pages 49-62

Pullen AM, Potts W, Wakeland EK, Kappler J, Marrack P

Abstract

We have examined TCR V beta expression in a collection of wild mice. Many of the mice were homozygous for a large deletion at the V beta locus, and many animals also suppressed expression of several V betas using self superantigens. Expression of V beta 8.2 was unexpectedly suppressed by a self superantigen in some wild mice, which was due to the presence in these animals of a variant V beta 8.2 gene. The amino acid changes in this gene product suggest contact sites between V beta and the superantigen. Although all V betas are expressed within each wild mouse population, individual mice have a limited and variable V beta repertoire. The independent origin of multiple V beta deletions and the presence of polymorphic self superantigens suggest that this variation may be maintained by balancing selection.

MeSH Terms
Amino Acid Sequence Animals Base Sequence Cell Line Chromosome Deletion Gene Expression Genes Haplotypes Mice/immunology Mice, Inbred Strains/immunology Molecular Sequence Data Oligonucleotide Probes Receptors, Antigen, T-Cell/genetics Sequence Homology, Nucleic Acid Species Specificity T-Lymphocytes/immunology
Chemicals
Oligonucleotide Probes Receptors, Antigen, T-Cell
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Pullen A M
Howard Hughes Medical Institute, Department of Medicine, Denver, Colorado 80206.
Potts W
Wakeland E K
Kappler J
Marrack P
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Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.171.1.49
Published
1990-01-01
Pages
49-62
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2187673
Subset
IM
Grants
NIAID NIH HHS · AI-17134 · United States
NIAID NIH HHS · AI-17966 · United States
NIAID NIH HHS · AI-18785 · United States
External Links
PubMed source DOI: 10.1084/jem.171.1.49 PMC Full Text View journal details
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