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PMID: 3035555 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Genomic organization of the mouse T-cell receptor beta-chain gene family.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 84 ·No. 11 ·1987-06-00 ·Pages 3846-50

Lai E, Barth RK, Hood L

Abstract

We have combined three different methods, deletion mapping of T-cell lines, field-inversion gel electrophoresis, and the restriction mapping of a cosmid clone, to construct a physical map of the murine T-cell receptor beta-chain gene family. We have mapped 19 variable (V beta) gene segments and the two clusters of diversity (D beta) and joining (J beta) gene segments and constant (C beta) genes. These members of the beta-chain gene family span approximately equal to 450 kilobases of DNA, excluding one potential gap in the DNA fragment alignments.

MeSH Terms
Animals Cell Line Chromosome Deletion Clone Cells DNA Restriction Enzymes Genes Macromolecular Substances Mice Receptors, Antigen, T-Cell/genetics
Chemicals
Macromolecular Substances Receptors, Antigen, T-Cell DNA Restriction Enzymes
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Lai E
Barth R K
Hood L
References (23)
23 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.84.11.3846
Published
1987-06-00
Pages
3846-50
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC304973
Subset
IM
Grants
NIAID NIH HHS · AI 17565 · United States
External Links
PubMed source DOI: 10.1073/pnas.84.11.3846 PMC Full Text View journal details
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