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PMID: 23165400 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't Review

Insight into oxidative stress in varicocele-associated male infertility: part 2.

Nature reviews. Urology ·Vol. 10 ·No. 1 ·2013-01-00 ·Pages 26-37

Hamada A, Esteves SC, Agarwal A

Abstract

Varicocele, the leading cause of male infertility, can impair spermatogenesis through several pathophysiological mechanisms. Of these, current evidence suggests that oxidative stress is the central element contributing to infertility in men with varicocele, to which the testis responds by way of heat stress, ischaemia or production of vasodilators, such as nitric oxide. Surgical varicocele repair (varicocelectomy) is beneficial not only for alleviating oxidative stress-associated infertility, but also for preventing and protecting against the progressive character of varicocele and its consequent upregulations of systemic oxidative stress. However, antioxidant therapy in infertile men with surgically treated and those with untreated varicocele is poorly studied, and well-designed trials are needed.

MeSH Terms
Adult Follow-Up Studies Humans Infertility, Male/etiology,prevention & control Male Malondialdehyde/metabolism Middle Aged Oxidative Stress/physiology Primary Prevention/methods Reactive Oxygen Species/metabolism Spermatogenesis/physiology Treatment Outcome Urologic Surgical Procedures, Male/methods Varicocele/complications,diagnosis,surgery Young Adult
Chemicals
Reactive Oxygen Species Malondialdehyde
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Hamada Alaa
Center for Reproductive Medicine, Glickman Urological and Kidney Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA.
Esteves Sandro C
Agarwal Ashok
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Article Info
Journal
Nature reviews. Urology
Abbr.
Nat Rev Urol
ISSN
1759-4820
DOI
10.1038/nrurol.2012.198
Published
2013-01-00
Epub
2012-00-20
Pages
26-37
Language
English
Region
England
NLM ID
101500082
Subset
IM
External Links
PubMed source DOI: 10.1038/nrurol.2012.198 View journal details
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