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PMID: 23165403 Published · ppublish English Journal Article Review

Insight into oxidative stress in varicocele-associated male infertility: part 1.

Nature reviews. Urology ·Vol. 9 ·No. 12 ·2012-12-00 ·Pages 678-90

Agarwal A, Hamada A, Esteves SC

Abstract

Varicocele is recognized as the leading cause of male infertility because it can impair spermatogenesis through several distinct pathophysiological mechanisms. Current evidence supports oxidative stress as a key element in the pathophysiology of varicocele-related infertility, although these mechanisms have not yet been fully described. Measurement of the reactive oxygen species and other markers of oxidative stress, including the levels of the antioxidant enzymes catalase and superoxide dismutase, can provide valuable information on the extent of oxidative stress and might guide therapeutic management strategies. The testis can respond to varicocele-associated cell stressors, such as heat stress, ischaemia or production of vasodilators (for example, nitric oxide) at the expense of the generation of excessive reactive oxygen species. These responses have their own implications in exacerbating the underlying oxidative stress and on the subsequent infertility.

MeSH Terms
Humans Infertility, Male/etiology,metabolism Male Oxidative Stress Testis/metabolism Varicocele/complications,metabolism
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Agarwal Ashok
Center for Reproductive Medicine, Glickman Urological and Kidney Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA. [email protected]
Hamada Alaa
Esteves Sandro C
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Article Info
Journal
Nature reviews. Urology
Abbr.
Nat Rev Urol
ISSN
1759-4820
DOI
10.1038/nrurol.2012.197
Email
[email protected]
Published
2012-12-00
Epub
2012-00-20
Pages
678-90
Language
English
Region
England
NLM ID
101500082
Subset
IM
External Links
PubMed source DOI: 10.1038/nrurol.2012.197 View journal details
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