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PMID: 23202124 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism.

Nature genetics ·Vol. 45 ·No. 1 ·2013-01-00 ·Pages 76-82

Horikoshi M, Yaghootkar H, Mook-Kanamori DO, Sovio U, Taal HR, Hennig BJ, Bradfield JP, St Pourcain B, Evans DM, Charoen P, Kaakinen M, Cousminer DL, Lehtimäki T, Kreiner-Møller E, Warrington NM, Bustamante M, Feenstra B, Berry DJ, Thiering E, Pfab T, Barton SJ, Shields BM, Kerkhof M, van Leeuwen EM, Fulford AJ, Kutalik Z, Zhao JH, den Hoed M, Mahajan A, Lindi V, Goh LK, Hottenga JJ, Wu Y, Raitakari OT, Harder MN, Meirhaeghe A, Ntalla I, Salem RM, Jameson KA, Zhou K, Monies DM, Lagou V, Kirin M, Heikkinen J, Adair LS, Alkuraya FS, Al-Odaib A, Amouyel P, Andersson EA, Bennett AJ, Blakemore AI, Buxton JL, Dallongeville J, Das S, de Geus EJ, Estivill X, Flexeder C, Froguel P, Geller F, Godfrey KM, Gottrand F, Groves CJ, Hansen T, Hirschhorn JN, Hofman A, Hollegaard MV, Hougaard DM, Hyppönen E, Inskip HM, Isaacs A, Jørgensen T, Kanaka-Gantenbein C, Kemp JP, Kiess W, Kilpeläinen TO, Klopp N, Knight BA, Kuzawa CW, McMahon G, Newnham JP, Niinikoski H, Oostra BA, Pedersen L, Postma DS, Ring SM, Rivadeneira F, Robertson NR, Sebert S, Simell O, Slowinski T, Tiesler CM, Tönjes A, Vaag A, Viikari JS, Vink JM, Vissing NH, Wareham NJ, Willemsen G, Witte DR, Zhang H, Zhao J, Meta-Analyses of Glucose- and Insulin-related traits Consortium MAGIC, Wilson JF, Stumvoll M, Prentice AM, Meyer BF, Pearson ER, Boreham CA, Cooper C, Gillman MW, Dedoussis GV, Moreno LA, Pedersen O, Saarinen M, Mohlke KL, Boomsma DI, Saw SM, Lakka TA, Körner A, Loos RJ, Ong KK, Vollenweider P, van Duijn CM, Koppelman GH, Hattersley AT, Holloway JW, Hocher B, Heinrich J, Power C, Melbye M, Guxens M, Pennell CE, Bønnelykke K, Bisgaard H, Eriksson JG, Widén E, Hakonarson H, Uitterlinden AG, Pouta A, Lawlor DA, Smith GD, Frayling TM, McCarthy MI, Grant SF, Jaddoe VW, Jarvelin MR, Timpson NJ, Prokopenko I, Freathy RM, Early Growth Genetics EGG Consortium

Abstract

Birth weight within the normal range is associated with a variety of adult-onset diseases, but the mechanisms behind these associations are poorly understood. Previous genome-wide association studies of birth weight identified a variant in the ADCY5 gene associated both with birth weight and type 2 diabetes and a second variant, near CCNL1, with no obvious link to adult traits. In an expanded genome-wide association meta-analysis and follow-up study of birth weight (of up to 69,308 individuals of European descent from 43 studies), we have now extended the number of loci associated at genome-wide significance to 7, accounting for a similar proportion of variance as maternal smoking. Five of the loci are known to be associated with other phenotypes: ADCY5 and CDKAL1 with type 2 diabetes, ADRB1 with adult blood pressure and HMGA2 and LCORL with adult height. Our findings highlight genetic links between fetal growth and postnatal growth and metabolism.

MeSH Terms
Adult Birth Weight/genetics Blood Pressure/genetics Body Height/genetics Diabetes Mellitus, Type 2/genetics Female Fetal Development/genetics Genetic Linkage Genetic Predisposition to Disease Genome-Wide Association Study Humans Infant, Newborn Male Meta-Analysis as Topic Polymorphism, Single Nucleotide Quantitative Trait Loci
Authors & Affiliations
150 authors, click to expand affiliations / ORCID
Horikoshi Momoko
Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.
Yaghootkar Hanieh
Mook-Kanamori Dennis O
Sovio Ulla
Taal H Rob
Hennig Branwen J
Bradfield Jonathan P
St Pourcain Beate
Evans David M
Charoen Pimphen
Kaakinen Marika
Cousminer Diana L
Lehtimäki Terho
Kreiner-Møller Eskil
Warrington Nicole M
Bustamante Mariona
Feenstra Bjarke
Berry Diane J
Thiering Elisabeth
Pfab Thiemo
Barton Sheila J
Shields Beverley M
Kerkhof Marjan
van Leeuwen Elisabeth M
Fulford Anthony J
Kutalik Zoltán
Zhao Jing Hua
den Hoed Marcel
Mahajan Anubha
Lindi Virpi
Goh Liang-Kee
Hottenga Jouke-Jan
Wu Ying
Raitakari Olli T
Harder Marie N
Meirhaeghe Aline
Ntalla Ioanna
Salem Rany M
Jameson Karen A
Zhou Kaixin
Monies Dorota M
Lagou Vasiliki
Kirin Mirna
Heikkinen Jani
Adair Linda S
Alkuraya Fowzan S
Al-Odaib Ali
Amouyel Philippe
Andersson Ehm Astrid
Bennett Amanda J
Blakemore Alexandra I F
Buxton Jessica L
Dallongeville Jean
Das Shikta
de Geus Eco J C
Estivill Xavier
Flexeder Claudia
Froguel Philippe
Geller Frank
Godfrey Keith M
Gottrand Frédéric
Groves Christopher J
Hansen Torben
Hirschhorn Joel N
Hofman Albert
Hollegaard Mads V
Hougaard David M
Hyppönen Elina
Inskip Hazel M
Isaacs Aaron
Jørgensen Torben
Kanaka-Gantenbein Christina
Kemp John P
Kiess Wieland
Kilpeläinen Tuomas O
Klopp Norman
Knight Bridget A
Kuzawa Christopher W
McMahon George
Newnham John P
Niinikoski Harri
Oostra Ben A
Pedersen Louise
Postma Dirkje S
Ring Susan M
Rivadeneira Fernando
Robertson Neil R
Sebert Sylvain
Simell Olli
Slowinski Torsten
Tiesler Carla M T
Tönjes Anke
Vaag Allan
Viikari Jorma S
Vink Jacqueline M
Vissing Nadja Hawwa
Wareham Nicholas J
Willemsen Gonneke
Witte Daniel R
Zhang Haitao
Zhao Jianhua
Meta-Analyses of Glucose- and Insulin-related traits Consortium (MAGIC)
Wilson James F
Stumvoll Michael
Prentice Andrew M
Meyer Brian F
Pearson Ewan R
Boreham Colin A G
Cooper Cyrus
Gillman Matthew W
Dedoussis George V
Moreno Luis A
Pedersen Oluf
Saarinen Maiju
Mohlke Karen L
Boomsma Dorret I
Saw Seang-Mei
Lakka Timo A
Körner Antje
Loos Ruth J F
Ong Ken K
Vollenweider Peter
van Duijn Cornelia M
Koppelman Gerard H
Hattersley Andrew T
Holloway John W
Hocher Berthold
Heinrich Joachim
Power Chris
Melbye Mads
Guxens Mònica
Pennell Craig E
Bønnelykke Klaus
Bisgaard Hans
Eriksson Johan G
Widén Elisabeth
Hakonarson Hakon
Uitterlinden André G
Pouta Anneli
Lawlor Debbie A
Smith George Davey
Frayling Timothy M
McCarthy Mark I
Grant Struan F A
Jaddoe Vincent W V
Jarvelin Marjo-Riitta
Timpson Nicholas J
Prokopenko Inga
Freathy Rachel M
Early Growth Genetics (EGG) Consortium
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Article Info
Journal
Nature genetics
Abbr.
Nat Genet
ISSN
1546-1718
DOI
10.1038/ng.2477
Published
2013-01-00
Epub
2012-00-02
Pages
76-82
Language
English
Region
United States
NLM ID
9216904
PMCID
PMC3605762
Subset
IM
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PubMed source DOI: 10.1038/ng.2477 PMC Full Text View journal details
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