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PMID: 23329111 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

RNA interference in the nucleus: roles for small RNAs in transcription, epigenetics and beyond.

Nature reviews. Genetics ·Vol. 14 ·No. 2 ·2013-02-00 ·Pages 100-12

Castel SE, Martienssen RA

Abstract

A growing number of functions are emerging for RNA interference (RNAi) in the nucleus, in addition to well-characterized roles in post-transcriptional gene silencing in the cytoplasm. Epigenetic modifications directed by small RNAs have been shown to cause transcriptional repression in plants, fungi and animals. Additionally, increasing evidence indicates that RNAi regulates transcription through interaction with transcriptional machinery. Nuclear small RNAs include small interfering RNAs (siRNAs) and PIWI-interacting RNAs (piRNAs) and are implicated in nuclear processes such as transposon regulation, heterochromatin formation, developmental gene regulation and genome stability.

MeSH Terms
Animals Arabidopsis/genetics,metabolism Caenorhabditis elegans/genetics,metabolism Cell Nucleus/genetics,metabolism DNA Methylation DNA Repair Drosophila melanogaster/genetics,metabolism Epigenesis, Genetic Female Germ Cells/metabolism Humans Male Mice Models, Biological RNA Interference RNA, Small Interfering/biosynthesis,classification,genetics Schizosaccharomyces/genetics,metabolism Transcription, Genetic
Chemicals
RNA, Small Interfering
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Castel Stephane E
Watson School of Biological Sciences, Cold Spring Harbor Laboratory, New York 11724, USA.
Martienssen Robert A
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Article Info
Journal
Nature reviews. Genetics
Abbr.
Nat Rev Genet
ISSN
1471-0064
DOI
10.1038/nrg3355
Published
2013-02-00
Pages
100-12
Language
English
Region
England
NLM ID
100962779
PMCID
PMC4205957
Subset
IM
Grants
NIGMS NIH HHS · R01 GM076396 · United States
External Links
PubMed source DOI: 10.1038/nrg3355 PMC Full Text View journal details
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